Hepatoprotective Role of Wheatgrass on Alcohol and ΔPUFA-Induced Oxidative Stress in Rats - PubMed (original) (raw)
Hepatoprotective Role of Wheatgrass on Alcohol and ΔPUFA-Induced Oxidative Stress in Rats
Varalakshmi Durairaj et al. J Diet Suppl. 2015 Jun.
Abstract
Alcohol abuse is recognized as the most common cause for the development of various abnormalities including liver disease. Excessive free radicals are generated during the metabolism of ethanol. The ingestion of alcohol along with polyunsaturated fatty acid (PUFA) aggravates the production of free radicals and enhances the oxidative stress. Medicinal plants contain active phytocomponents, which are the principal healthcare resources. We aimed to analyze the effect of wheatgrass extract on alcohol and thermally oxidized PUFA (ΔPUFA) induced oxidative stress in male albino Wistar rats. The levels of marker enzymes gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), lipid peroxidative markers; thiobarbutric acid reactive substances (TBARS) and lipid hydroperoxides (LH), the levels of enzymatic (catalase [CAT], superoxide dismutase [SOD], glutathione peroxidase [GPx]) and nonenzymatic (reduced glutathione [GSH], vitamin E, vitamin C) antioxidants were analyzed in liver to evaluate the effects of wheatgrass. The levels of TBARS and LH were significantly (p ≤ .05) increased in alcohol + ΔPUFA group, which were found to be reduced on treatment with wheatgrass. The levels of both enzymatic and nonenzymatic antioxidants were significantly (p ≤ .05) decreased in alcohol + ΔPUFA group, which were found to be restored on treatment with wheatgrass. From the results obtained, we conclude that wheatgrass protects the liver against alcohol and ΔPUFA induced oxidative stress.
Keywords: Alcohol; liver; liver marker enzyme; oxidative stress; wheatgrass; ΔPUFA.
Similar articles
- Hepatoprotective role of kaempferol during alcohol- and ΔPUFA-induced oxidative stress.
Shakya G, Manjini S, Hoda M, Rajagopalan R. Shakya G, et al. J Basic Clin Physiol Pharmacol. 2014 Feb;25(1):73-9. doi: 10.1515/jbcpp-2013-0051. J Basic Clin Physiol Pharmacol. 2014. PMID: 23893680 - Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress.
Rukkumani R, Aruna K, Varma PS, Rajasekaran KN, Menon VP. Rukkumani R, et al. J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. J Pharm Pharm Sci. 2004. PMID: 15367386 - Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity.
Rukkumani R, Aruna K, Varma PS, Menon VP. Rukkumani R, et al. J Physiol Pharmacol. 2004 Sep;55(3):551-61. J Physiol Pharmacol. 2004. PMID: 15381826 - [The action of oxidative stress induced by ethanol on the central nervous system (CNS)].
Augustyniak A, Michalak K, Skrzydlewska E. Augustyniak A, et al. Postepy Hig Med Dosw (Online). 2005;59:464-71. Postepy Hig Med Dosw (Online). 2005. PMID: 16258411 Review. Polish. - [Lipid peroxidation and free radicals. Role in cellular biology and pathology].
Clavel JP, Emerit J, Thuillier A. Clavel JP, et al. Pathol Biol (Paris). 1985 Jan;33(1):61-9. Pathol Biol (Paris). 1985. PMID: 2983288 Review. French.
Cited by
- Attenuative Effects of Fluoxetine and Triticum aestivum against Aluminum-Induced Alzheimer's Disease in Rats: The Possible Consequences on Hepatotoxicity and Nephrotoxicity.
Abu-Elfotuh K, Ragab GM, Salahuddin A, Jamil L, Abd Al Haleem EN. Abu-Elfotuh K, et al. Molecules. 2021 Nov 8;26(21):6752. doi: 10.3390/molecules26216752. Molecules. 2021. PMID: 34771159 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous