A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor - PubMed (original) (raw)

Comparative Study

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

S Yonehara et al. J Exp Med. 1989.

Abstract

We have prepared an mAb specific for a human cell surface component (termed anti-Fas mAb). Anti-Fas shows cell-killing activity that is indistinguishable from the cytolytic activity of TNF. Fas antigen was characterized by western blotting, indicating that Fas antigen is a cell surface protein with a molecular weight of 200,000, which is different from the molecular weight of TNF-R. Fas antigen, however, is co-downregulated with the TNF-R when cells sensitive to the cytolytic activity of TNF are incubated with either TNF or anti-Fas. In contrast, Fas antigen on cells insensitive to TNF is not co-downregulated with the TNF-R. We suggest that the cell-killing activity of TNF is mediated by Fas antigen associated with the TNF-R.

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References

1. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3666-70 - PubMed
1. J Biol Chem. 1988 Dec 15;263(35):19098-104 - PubMed
1. J Virol. 1983 Mar;45(3):1168-71 - PubMed
1. J Biol Chem. 1983 Aug 10;258(15):9046-9 - PubMed
1. Nature. 1984 Dec 20-1985 Jan 2;312(5996):724-9 - PubMed

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A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor - PubMed (original) (raw)