Occurrence of B-cell lymphomas in patients with activated phosphoinositide 3-kinase δ syndrome - PubMed (original) (raw)

doi: 10.1016/j.jaci.2014.02.020. Epub 2014 Apr 1.

James Curtis 2, Mohammad A A Ibrahim 3, Anna Sediva 4, Jon Salisbury 5, Vit Campr 6, Marianne Debré 7, J David M Edgar 8, Kohsuke Imai 9, Capucine Picard 10, Jean-Laurent Casanova 11, Alain Fischer 12, Sergey Nejentsev 13, Anne Durandy 14

Affiliations

Occurrence of B-cell lymphomas in patients with activated phosphoinositide 3-kinase δ syndrome

Sven Kracker et al. J Allergy Clin Immunol. 2014 Jul.

No abstract available

PubMed Disclaimer

Figures

Figure 1

Figure 1

B-cell lymphomas. Histological staining of patient 1: (A) H&E (200×); (B) CD79a and (C) Ki67 staining of DLBCL of the biliary tract. (D) H&E (200×); (E) CD20 and (F) Bcl-2 staining of DLBCL of the colon. Histological staining of patient 2 showing view atypical large cells: (G) H&E (200×); (H) CD30 and (I) CD3 staining of Hodgkin lymphoma of a cervical lymph node.

References

    1. Angulo I, Vadas O, Garcon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debre M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S. Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage. Science. 2013;342:866–871. - PMC - PubMed
    1. Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G. Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110delta result in T cell senescence and human immunodeficiency. Nat Immunol. 2014;15:88–97. - PMC - PubMed
    1. Kang S, Denley A, Vanhaesebroeck B, Vogt PK. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2006;103:1289–1294. - PMC - PubMed
    1. Sander S, Calado DP, Srinivasan L, Kochert K, Zhang B, Rosolowski M, Rodig SJ, Holzmann K, Stilgenbauer S, Siebert R, Bullinger L, Rajewsky K. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell. 2012;22:167–179. - PMC - PubMed
    1. Rickert RC. New insights into pre-BCR and BCR signalling with relevance to B cell malignancies. Nat Rev Immunol. 2013;13:578–591. - PubMed

Publication types

MeSH terms

Substances

Supplementary concepts

LinkOut - more resources