The molecular basis of muscarinic receptor diversity - PubMed (original) (raw)
Review
The molecular basis of muscarinic receptor diversity
T I Bonner. Trends Neurosci. 1989 Apr.
Abstract
The cloning of cDNAs and genes for five different muscarinic acetylcholine receptors provides a new basis for characterizing muscarinic receptor function. Studies of the cloned receptors when introduced into cells not expressing endogenous receptors have allowed the initial identification of two classes of functional response. The m1, m3 and m5 receptors belong to a class characterized by agonist-induced stimulation of phosphatidylinositol metabolism and are structurally more related to each other than they are to the m2 and m4 receptors, which belong to a class associated with agonist-induced inhibition of adenylate cyclase. While functional differences within these classes may yet be found, it appears likely that much of the difference between functionally similar receptors will be found to lie in their regulation.
Similar articles
- Expression of muscarinic receptor subtypes in salivary glands of rats, sheep and man.
Ryberg AT, Warfvinge G, Axelsson L, Soukup O, Götrick B, Tobin G. Ryberg AT, et al. Arch Oral Biol. 2008 Jan;53(1):66-74. doi: 10.1016/j.archoralbio.2007.07.012. Epub 2007 Sep 6. Arch Oral Biol. 2008. PMID: 17825245 - Diverse functions of muscarinic acetylcholine receptor subtypes.
Lechleiter J, Peralta E, Clapham D. Lechleiter J, et al. Trends Pharmacol Sci. 1989 Dec;Suppl:34-8. Trends Pharmacol Sci. 1989. PMID: 2694520 Review. - New subtypes of muscarinic acetylcholine receptors.
Bonner TI. Bonner TI. Trends Pharmacol Sci. 1989 Dec;Suppl:11-5. Trends Pharmacol Sci. 1989. PMID: 2694516 Review.
Cited by
- Basal forebrain cholinergic systems as circuits through which traumatic stress disrupts emotional memory regulation.
Knox D, Parikh V. Knox D, et al. Neurosci Biobehav Rev. 2024 Apr;159:105569. doi: 10.1016/j.neubiorev.2024.105569. Epub 2024 Feb 1. Neurosci Biobehav Rev. 2024. PMID: 38309497 Review. - Potential antiproliferative and apoptotic effects of pilocarpine combined with TNF alpha in chronic myeloid leukemia cells.
Kanlı Z, Cabadak H, Aydın B. Kanlı Z, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul;396(7):1513-1524. doi: 10.1007/s00210-023-02418-4. Epub 2023 Feb 13. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 36781441 - Multitargeting nature of muscarinic orthosteric agonists and antagonists.
Myslivecek J. Myslivecek J. Front Physiol. 2022 Sep 6;13:974160. doi: 10.3389/fphys.2022.974160. eCollection 2022. Front Physiol. 2022. PMID: 36148314 Free PMC article. Review. - Muscarinic Acetylcholine Receptors in the Retina-Therapeutic Implications.
Ruan Y, Patzak A, Pfeiffer N, Gericke A. Ruan Y, et al. Int J Mol Sci. 2021 May 8;22(9):4989. doi: 10.3390/ijms22094989. Int J Mol Sci. 2021. PMID: 34066677 Free PMC article. Review. - Autoradiographic Distribution of Muscarinic Acetylcholine Receptor Subtypes in Rat Cochlear Nucleus.
Yao W, Godfrey DA. Yao W, et al. Audit Neurosci. 1996;2:241-255. Audit Neurosci. 1996. PMID: 33510562 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases