The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats - PubMed (original) (raw)
The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats
Mohamed S Othman et al. Food Chem Toxicol. 2014 Jul.
Abstract
Mercury (Hg) is the third most dangerous heavy metal after arsenic and lead. Mercury's toxicity brings serious risks to health through negative pathological and biochemical effects. The study was designed to investigate the possible protective role of berberine (BN) in mercuric chloride (HgCl2) induced oxidative stress in hepatic and renal tissues. Adult male albino Wistar rats were exposed to mercuric chloride (HgCl2; 0.4 mg/kg bwt) for 7 days. Treatment with HgCl2 induced oxidative stress by increasing lipid peroxidation and nitric oxide production along with a concomitant decrease in glutathione and various antioxidant enzymes, namely superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. HgCl2 intoxication increased the activities of liver enzymes and the bilirubin level, in addition to the levels of urea and creatinine in serum. BN (100mg/kg bwt) treatment inhibited lipid peroxidation and nitric oxide production, whereas it increased glutathione content. Activities of antioxidants enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, were also restored concomitantly when compared to control after BN administration. BN also inhibited the apoptotic effect of HgCl2 by increasing the expression of Bcl-2 protein in liver and kidney. Histopathological examination of the liver and kidney tissues proved the protective effect of BN against HgCl2 toxicity. These results demonstrated that BN augments antioxidant defense against HgCl2-induced toxicity and provides evidence that it has therapeutic potential as hepato- and reno-protective agent.
Keywords: Apoptosis; Berberine; Kidney; Liver; Mercuric chloride; Oxidative stress.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Similar articles
- The neuroprotective effect of berberine in mercury-induced neurotoxicity in rats.
Abdel Moneim AE. Abdel Moneim AE. Metab Brain Dis. 2015 Aug;30(4):935-42. doi: 10.1007/s11011-015-9652-6. Epub 2015 Jan 21. Metab Brain Dis. 2015. PMID: 25600690 - Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach.
Joshi D, Srivastav SK, Belemkar S, Dixit VA. Joshi D, et al. Biomed Pharmacother. 2017 Jul;91:645-655. doi: 10.1016/j.biopha.2017.04.108. Epub 2017 May 8. Biomed Pharmacother. 2017. PMID: 28494418 - N-acetyl cysteine and selenium protects mercuric chloride-induced oxidative stress and antioxidant defense system in liver and kidney of rats: a histopathological approach.
Joshi D, Mittal DK, Shukla S, Srivastav AK, Srivastav SK. Joshi D, et al. J Trace Elem Med Biol. 2014 Apr;28(2):218-226. doi: 10.1016/j.jtemb.2013.12.006. Epub 2014 Jan 8. J Trace Elem Med Biol. 2014. PMID: 24485406 - [HgCl2-induced acute renal failure and its pathophysiology].
Yanagisawa H. Yanagisawa H. Nihon Eiseigaku Zasshi. 1998 Jan;52(4):618-23. doi: 10.1265/jjh.52.618. Nihon Eiseigaku Zasshi. 1998. PMID: 9528259 Review. Japanese. - The pharmacological activity of berberine, a review for liver protection.
Zhou M, Deng Y, Liu M, Liao L, Dai X, Guo C, Zhao X, He L, Peng C, Li Y. Zhou M, et al. Eur J Pharmacol. 2021 Jan 5;890:173655. doi: 10.1016/j.ejphar.2020.173655. Epub 2020 Oct 14. Eur J Pharmacol. 2021. PMID: 33068590 Review.
Cited by
- An Insight into Different Experimental Models used for Hepatoprotective Studies: A Review.
Babu S, Ranajit SK, Pattnaik G, Ghosh G, Rath G, Kar B. Babu S, et al. Curr Drug Discov Technol. 2024;21(4):e191223224660. doi: 10.2174/0115701638278844231214115102. Curr Drug Discov Technol. 2024. PMID: 39206705 Review. - Biochemical, morphological and molecular assessments of n butanol fraction of Phoenix dactylifera L. following exposure to inorganic mercury on the liver of Wistar rats.
Abubakar MG, Agbon AN, Musa SA, Hamman WO, Oladele SB. Abubakar MG, et al. Lab Anim Res. 2024 Apr 19;40(1):15. doi: 10.1186/s42826-024-00203-9. Lab Anim Res. 2024. PMID: 38641806 Free PMC article. - Green-Synthesized Silver and Selenium Nanoparticles Using Berberine: A Comparative Assessment of In Vitro Anticancer Potential on Human Hepatocellular Carcinoma Cell Line (HepG2).
Khaled AM, Othman MS, Obeidat ST, Aleid GM, Aboelnaga SM, Fehaid A, Hathout HMR, Bakkar AA, Moneim AEA, El-Garawani IM, Morsi DS. Khaled AM, et al. Cells. 2024 Feb 5;13(3):287. doi: 10.3390/cells13030287. Cells. 2024. PMID: 38334679 Free PMC article. - Berberine alleviates chlorpyrifos-induced nephrotoxicity in rats via modulation of Nrf2/HO-1 axis.
Binmahfouz LS, Hassanein EHM, Bagher AM, Hareeri RH, Alamri ZZ, Algandaby MM, Abdel-Daim MM, Abdel-Naim AB. Binmahfouz LS, et al. Heliyon. 2024 Jan 29;10(3):e25233. doi: 10.1016/j.heliyon.2024.e25233. eCollection 2024 Feb 15. Heliyon. 2024. PMID: 38327393 Free PMC article. - Coenzyme Q10-Loaded Albumin Nanoparticles Protect against Redox Imbalance and Inflammatory, Apoptotic, and Histopathological Alterations in Mercuric Chloride-Induced Hepatorenal Toxicity in Rats.
Ramadan SS, El Zaiat FA, Habashy EA, Montaser MM, Hassan HE, Tharwat SS, El-Khadragy M, Abdel Moneim AE, Elshopakey GE, Akabawy AMA. Ramadan SS, et al. Biomedicines. 2023 Nov 14;11(11):3054. doi: 10.3390/biomedicines11113054. Biomedicines. 2023. PMID: 38002054 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources