A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia - PubMed (original) (raw)
Clinical Trial
. 1989 Oct 26;321(17):1141-8.
doi: 10.1056/NEJM198910263211701.
Affiliations
- PMID: 2477702
- DOI: 10.1056/NEJM198910263211701
Clinical Trial
A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia
J J Goedert et al. N Engl J Med. 1989.
Abstract
We evaluated a multicenter cohort of 1219 subjects with hemophilia or related disorders prospectively, focusing on 319 subjects with documented dates of seroconversion to human immunodeficiency virus type 1 (HIV-1). The incidence rate of the acquired immunodeficiency syndrome (AIDS) after seroconversion was 2.67 per 100 person-years and was directly related to age (from 0.83 in persons 1 to 11 years old up to 5.66 in persons 35 to 70 years old; Ptrend = 0.00003). The annual incidence of AIDS ranged from zero during the first year after seroconversion to 7 percent during the eighth year, with eight-year cumulative rates (+/- SE) of 13.3 +/- 5.3 percent for ages 1 to 17, 26.8 +/- 6.4 percent for ages 18 to 34, and 43.7 +/- 16.4 percent for ages 35 to 70. Serial immunologic and virologic markers (total numbers of CD4 lymphocytes, presence of serum interferon or HIV-1 p24 antigen, and low or absent serum levels of anti-p24 or anti-gp120) predicted a high risk for the subsequent development of AIDS. Adults 35 to 70 years old had a higher incidence of low CD4 counts than younger subjects (P less than or equal to 0.005), whereas adolescents had a low rate of anti-p24 loss (P = 0.0007) and subjects 1 to 17 years old had a lower incidence of AIDS after loss of anti-p24 (P = 0.03). These findings not only demonstrate that the risk of AIDS is related directly to age but also suggest that older adults are disproportionately affected during the earlier phases of HIV disease, that adolescents may have a low replication rate of HIV, and that children and adolescents may tolerate severe immunodeficiency better because they have fewer other infections or because of some unmeasured, age-dependent cofactor or immune alteration in the later phase of HIV disease.
Comment in
- AIDS in subjects with hemophilia.
[No authors listed] [No authors listed] N Engl J Med. 1990 Apr 26;322(17):1232-4. doi: 10.1056/NEJM199004263221712. N Engl J Med. 1990. PMID: 2325715 No abstract available.
Similar articles
- Progression to acquired immunodeficiency syndrome in 94 human immunodeficiency virus-positive hemophiliacs with long-term follow-up.
Lorenzo JI, Moscardó F, López-Aldeguer J, Aznar JA. Lorenzo JI, et al. Haematologica. 2001 Mar;86(3):291-6. Haematologica. 2001. PMID: 11357820 - Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases.
Volberding PA, Lagakos SW, Koch MA, Pettinelli C, Myers MW, Booth DK, Balfour HH Jr, Reichman RC, Bartlett JA, Hirsch MS, et al. Volberding PA, et al. N Engl J Med. 1990 Apr 5;322(14):941-9. doi: 10.1056/NEJM199004053221401. N Engl J Med. 1990. PMID: 1969115 Clinical Trial. - Long-term evaluation of HIV antigen and antibodies to p24 and gp41 in patients with hemophilia. Potential clinical importance.
Allain JP, Laurian Y, Paul DA, Verroust F, Leuther M, Gazengel C, Senn D, Larrieu MJ, Bosser C. Allain JP, et al. N Engl J Med. 1987 Oct 29;317(18):1114-21. doi: 10.1056/NEJM198710293171804. N Engl J Med. 1987. PMID: 3477695 - AIDS and hemophilia: experience in the La Paz Hemophilia Center.
Magallón Martínez M, Ortega F, Pinilla J. Magallón Martínez M, et al. Haemostasis. 1992;22(5):281-92. doi: 10.1159/000216336. Haemostasis. 1992. PMID: 1362177 Review. - Factor VIII, HIV and AIDS in haemophiliacs: an analysis of their relationship.
Papadopulos-Eleopulos E, Turner VF, Papadimitriou JM, Causer D. Papadopulos-Eleopulos E, et al. Genetica. 1995;95(1-3):25-50. doi: 10.1007/BF01435000. Genetica. 1995. PMID: 7538088 Review.
Cited by
- The Role of Microbial Translocation and Immune Activation in AIDS-Associated Non-Hodgkin Lymphoma Pathogenesis: What Have We Learned?
Epeldegui M, Hussain SK. Epeldegui M, et al. Crit Rev Immunol. 2020;40(1):41-51. doi: 10.1615/CritRevImmunol.2020033319. Crit Rev Immunol. 2020. PMID: 32421978 Free PMC article. Review. - Gene therapy for haemophilia.
Sharma A, Easow Mathew M, Sriganesh V, Reiss UM. Sharma A, et al. Cochrane Database Syst Rev. 2020 Apr 28;4(4):CD010822. doi: 10.1002/14651858.CD010822.pub4. Cochrane Database Syst Rev. 2020. PMID: 32342499 Free PMC article. - Mechanisms of secretion and spreading of pathological tau protein.
Brunello CA, Merezhko M, Uronen RL, Huttunen HJ. Brunello CA, et al. Cell Mol Life Sci. 2020 May;77(9):1721-1744. doi: 10.1007/s00018-019-03349-1. Epub 2019 Oct 30. Cell Mol Life Sci. 2020. PMID: 31667556 Free PMC article. Review. - Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1.
Boelen L, Debebe B, Silveira M, Salam A, Makinde J, Roberts CH, Wang ECY, Frater J, Gilmour J, Twigger K, Ladell K, Miners KL, Jayaraman J, Traherne JA, Price DA, Qi Y, Martin MP, Macallan DC, Thio CL, Astemborski J, Kirk G, Donfield SM, Buchbinder S, Khakoo SI, Goedert JJ, Trowsdale J, Carrington M, Kollnberger S, Asquith B. Boelen L, et al. Sci Immunol. 2018 Nov 9;3(29):eaao2892. doi: 10.1126/sciimmunol.aao2892. Sci Immunol. 2018. PMID: 30413420 Free PMC article. - A cross-sectional analysis of cardiovascular disease in the hemophilia population.
Sood SL, Cheng D, Ragni M, Kessler CM, Quon D, Shapiro AD, Key NS, Manco-Johnson MJ, Cuker A, Kempton C, Wang TF, Eyster ME, Kuriakose P, von Drygalski A, Gill JC, Wheeler A, Kouides P, Escobar MA, Leissinger C, Galdzicka S, Corson M, Watson C, Konkle BA. Sood SL, et al. Blood Adv. 2018 Jun 12;2(11):1325-1333. doi: 10.1182/bloodadvances.2018018226. Blood Adv. 2018. PMID: 29895623 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials