Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation - PubMed (original) (raw)
. 1989 Dec 1;143(11):3461-9.
Affiliations
- PMID: 2479679
Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation
D S Ucker et al. J Immunol. 1989.
Abstract
We have observed that stimuli that are mitogenic for normal T cells can induce cell death in transformed T cell hybridomas. "Activation-driven cell death" can be triggered by the presentation of appropriate Ag as well as by treatment with lectins and antibodies specific for the T cell Ag receptor complex and other activation structures on the T cell surface, such as Thy-1 and Ly-6. The activation-driven lethal process is cell autonomous, is associated with a fragmentation of the cell's genome characteristic of the "suicide process" induced in immature T cells by glucocorticoids and in target cells by cytotoxic T lymphocytes, and is dependent upon transcription and translation, presumably associated with the expression of new gene products. We hypothesize that activation-driven cell death may be involved in vivo in the clonal deletion of auto-reactive T cells during T cell ontogeny.
Similar articles
- A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.
Pierres A, Naquet P, Van Agthoven A, Bekkhoucha F, Denizot F, Mishal Z, Schmitt-Verhulst AM, Pierres M. Pierres A, et al. J Immunol. 1984 Jun;132(6):2775-82. J Immunol. 1984. PMID: 6202760 - Role of accessory molecules in signal transduction of cytolytic T lymphocyte by anti-T cell receptor and anti-Ly-6.2C monoclonal antibodies.
Leo O, Foo M, Henkart PA, Perez P, Shinohara N, Segal DM, Bluestone JA. Leo O, et al. J Immunol. 1987 Dec 1;139(11):3556-63. J Immunol. 1987. PMID: 3316387 - Anti-T3 antibody both activates and inhibits the cytotoxic activity of human T cell clones.
Hoffman RW, Quinones RR, Shaw S. Hoffman RW, et al. Behring Inst Mitt. 1985 Aug;(77):30-8. Behring Inst Mitt. 1985. PMID: 3936472 Review. - Regulation of the immune response T-cell interactions.
Dutton RW, Swain SL. Dutton RW, et al. CRC Crit Rev Immunol. 1982 Feb;3(3):209-61. CRC Crit Rev Immunol. 1982. PMID: 6176399 Review. No abstract available.
Cited by
- PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond.
Ishida Y. Ishida Y. Cells. 2020 Jun 1;9(6):1376. doi: 10.3390/cells9061376. Cells. 2020. PMID: 32492969 Free PMC article. Review. - Engaging Ly-6A/Sca-1 triggers lipid raft-dependent and -independent responses in CD4+ T-cell lines.
Lang MA, Jenkins SA, Balzano P, Owoyele A, Patel A, Bamezai AK. Lang MA, et al. Immun Inflamm Dis. 2017 Dec;5(4):448-460. doi: 10.1002/iid3.182. Epub 2017 Jun 28. Immun Inflamm Dis. 2017. PMID: 28660664 Free PMC article. - Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.
Seedhom MO, Mathurin KS, Kim SK, Welsh RM. Seedhom MO, et al. J Virol. 2012 Jun;86(11):6010-22. doi: 10.1128/JVI.07176-11. Epub 2012 Mar 21. J Virol. 2012. PMID: 22438562 Free PMC article. - The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung.
Ormerod AK, Xing Z, Pedigo NG, Mishra A, Kaetzel DM. Ormerod AK, et al. Exp Lung Res. 2008 May;34(4):155-82. doi: 10.1080/01902140801929325. Exp Lung Res. 2008. PMID: 18432454 Free PMC article. - Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells.
Doyle AM, Mullen AC, Villarino AV, Hutchins AS, High FA, Lee HW, Thompson CB, Reiner SL. Doyle AM, et al. J Exp Med. 2001 Oct 1;194(7):893-902. doi: 10.1084/jem.194.7.893. J Exp Med. 2001. PMID: 11581312 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Miscellaneous