Nuclear factors interacting with an interleukin-6 responsive element of rat alpha 2-macroglobulin gene - PubMed (original) (raw)
Nuclear factors interacting with an interleukin-6 responsive element of rat alpha 2-macroglobulin gene
T Ito et al. Nucleic Acids Res. 1989.
Free PMC article
Abstract
During acute inflammation, a group of liver-derived plasma proteins, acute phase proteins (APPs), increase in concentration. Interleukin-6 (IL-6) is responsible for this increase via the induction of APP gene expression. We have identified an IL-6 responsive cis-acting element (IL-6RE) of gene encoding a typical APP, rat alpha 2-macroglobulin (alpha 2M). The IL-6RE contains a sequence that is conserved among the 5'-flanking regions of various APP genes. Introduction of mutations into the conserved sequence revealed that the sequence, termed IL-6RE core, is a critical and essential component of IL6-RE. Nuclear factors binding to the IL-6RE core were identified in livers of normal and inflamed rats. Mobility shift pattern and DNase I footprinting profile indicated that the factors from normal and inflamed stages recognized the same sequence but were distinct from each other. These results suggested that the regulation of alpha 2M gene expression may involve mutually exclusive interaction of stage-specific trans-acting factors.
Similar articles
- Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.
Hattori M, Abraham LJ, Northemann W, Fey GH. Hattori M, et al. Proc Natl Acad Sci U S A. 1990 Mar;87(6):2364-8. doi: 10.1073/pnas.87.6.2364. Proc Natl Acad Sci U S A. 1990. PMID: 1690431 Free PMC article. - Prolactin induction of the alpha 2-Macroglobulin gene in rat ovarian granulosa cells: stat 5 activation and binding to the interleukin-6 response element.
Dajee M, Kazansky AV, Raught B, Hocke GM, Fey GH, Richards JS. Dajee M, et al. Mol Endocrinol. 1996 Feb;10(2):171-84. doi: 10.1210/mend.10.2.8825557. Mol Endocrinol. 1996. PMID: 8825557 - Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene.
Hocke GM, Barry D, Fey GH. Hocke GM, et al. Mol Cell Biol. 1992 May;12(5):2282-94. doi: 10.1128/mcb.12.5.2282-2294.1992. Mol Cell Biol. 1992. PMID: 1373812 Free PMC article. - Gene regulation by interleukin 6.
Fey GH, Hattori M, Hocke G, Brechner T, Baffet G, Baumann M, Baumann H, Northemann W. Fey GH, et al. Biochimie. 1991 Jan;73(1):47-50. doi: 10.1016/0300-9084(91)90073-a. Biochimie. 1991. PMID: 2031958 Review. - Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin.
Krause E, Wegenka U, Möller C, Horn F, Heinrich PC. Krause E, et al. Biol Chem Hoppe Seyler. 1992 Jul;373(7):509-15. doi: 10.1515/bchm3.1992.373.2.509. Biol Chem Hoppe Seyler. 1992. PMID: 1381187 Review. No abstract available.
Cited by
- Cell-type and transcription factor specific enrichment of transcriptional cofactor motifs in ENCODE ChIP-seq data.
Goi C, Little P, Xie C. Goi C, et al. BMC Genomics. 2013;14 Suppl 5(Suppl 5):S2. doi: 10.1186/1471-2164-14-S5-S2. Epub 2013 Oct 16. BMC Genomics. 2013. PMID: 24564528 Free PMC article. - Transcriptional profiling of intrinsic PNS factors in the postnatal mouse.
Smith RP, Lerch-Haner JK, Pardinas JR, Buchser WJ, Bixby JL, Lemmon VP. Smith RP, et al. Mol Cell Neurosci. 2011 Jan;46(1):32-44. doi: 10.1016/j.mcn.2010.07.015. Epub 2010 Aug 7. Mol Cell Neurosci. 2011. PMID: 20696251 Free PMC article. - Bioinformatic identification of novel putative photoreceptor specific cis-elements.
Danko CG, McIlvain VA, Qin M, Knox BE, Pertsov AM. Danko CG, et al. BMC Bioinformatics. 2007 Oct 22;8:407. doi: 10.1186/1471-2105-8-407. BMC Bioinformatics. 2007. PMID: 17953763 Free PMC article. - Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
Zhang X, Wrzeszczynska MH, Horvath CM, Darnell JE Jr. Zhang X, et al. Mol Cell Biol. 1999 Oct;19(10):7138-46. doi: 10.1128/MCB.19.10.7138. Mol Cell Biol. 1999. PMID: 10490649 Free PMC article. - Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.
Wen Z, Darnell JE Jr. Wen Z, et al. Nucleic Acids Res. 1997 Jun 1;25(11):2062-7. doi: 10.1093/nar/25.11.2062. Nucleic Acids Res. 1997. PMID: 9153303 Free PMC article.
References
- Nucleic Acids Res. 1978 Sep;5(9):3157-70 - PubMed
- Gene. 1989 Apr 30;77(2):333-40 - PubMed
- Nucleic Acids Res. 1981 Dec 11;9(23):6505-25 - PubMed
- Ann N Y Acad Sci. 1982;389:39-48 - PubMed
- Mol Cell Biol. 1982 Sep;2(9):1044-51 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical