Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats - PubMed (original) (raw)
Review
Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats
Johan G Olsen et al. Cytokine Growth Factor Rev. 2014 Jun.
Abstract
For decades, a spectacular structural motif has been the focus of research in two families of animal membrane proteins: the hematopoietic cytokine type I receptors (HCR) and the thrombospondin repeat type 1 (TSR-1) domain containing proteins. Although these families include some of the best-studied and pharmaceutically most interesting human proteins, the function of the motif remains elusive. Here we show that the molecular details of the motifs are the same; that it has arisen through convergent evolution, and we argue that the same ligand binding function is maintained and suggest that the ligand can be found in the extracellular matrix (ECM). We term the motif the tryptophan ladder and suggest a function based on a comparative analysis.
Keywords: Cytokine type I receptor; Glycosaminoglycans; Thrombospondin type 1 repeat; WS-motif; WSXWS.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Similar articles
- The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor.
Dagil R, Knudsen MJ, Olsen JG, O'Shea C, Franzmann M, Goffin V, Teilum K, Breinholt J, Kragelund BB. Dagil R, et al. Structure. 2012 Feb 8;20(2):270-82. doi: 10.1016/j.str.2011.12.010. Structure. 2012. PMID: 22325776 - The proline-rich motif (PRM): a novel feature of the cytokine/hematopoietin receptor superfamily.
O'Neal KD, Yu-Lee LY. O'Neal KD, et al. Lymphokine Cytokine Res. 1993 Oct;12(5):309-12. Lymphokine Cytokine Res. 1993. PMID: 8260540 - The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region.
Kernebeck T, Pflanz S, Müller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grötzinger J. Kernebeck T, et al. Protein Sci. 1999 Jan;8(1):5-12. doi: 10.1110/ps.8.1.5. Protein Sci. 1999. PMID: 10210178 Free PMC article. - The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development.
Adams JC, Tucker RP. Adams JC, et al. Dev Dyn. 2000 Jun;218(2):280-99. doi: 10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. Dev Dyn. 2000. PMID: 10842357 Review. - Structure and function of aggrecan.
Kiani C, Chen L, Wu YJ, Yee AJ, Yang BB. Kiani C, et al. Cell Res. 2002 Mar;12(1):19-32. doi: 10.1038/sj.cr.7290106. Cell Res. 2002. PMID: 11942407 Review.
Cited by
- The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans.
Ahmad I, Lokau J, Kespohl B, Malik NA, Baig SM, Hartig R, Behme D, Schwab R, Altmüller J, Jameel M, Mucha S, Thiele H, Tariq M, Nürnberg P, Erdmann J, Garbers C. Ahmad I, et al. Sci Rep. 2023 Aug 18;13(1):13479. doi: 10.1038/s41598-023-39466-y. Sci Rep. 2023. PMID: 37596289 Free PMC article. - Structure and function insights garnered from in silico modeling of the thrombospondin type-1 domain-containing 7A antigen.
Stoddard SV, Welsh CL, Palopoli MM, Stoddard SD, Aramandla MP, Patel RM, Ma H, Beck LH Jr. Stoddard SV, et al. Proteins. 2019 Feb;87(2):136-145. doi: 10.1002/prot.25640. Epub 2018 Dec 21. Proteins. 2019. PMID: 30520531 Free PMC article. - A _Plasmodium falciparum C_-mannosyltransferase is dispensable for parasite asexual blood stage development.
López-Gutiérrez B, Cova M, Izquierdo L. López-Gutiérrez B, et al. Parasitology. 2019 Dec;146(14):1767-1772. doi: 10.1017/S0031182019001380. Epub 2019 Oct 23. Parasitology. 2019. PMID: 31559936 Free PMC article. - Structural modeling of cytokine-receptor-JAK2 signaling complexes using AlphaFold Multimer.
Pogozheva ID, Cherepanov S, Park SJ, Raghavan M, Im W, Lomize AL. Pogozheva ID, et al. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544971. doi: 10.1101/2023.06.14.544971. bioRxiv. 2023. PMID: 37398331 Free PMC article. Updated. Preprint. - Order and disorder-An integrative structure of the full-length human growth hormone receptor.
Kassem N, Araya-Secchi R, Bugge K, Barclay A, Steinocher H, Khondker A, Wang Y, Lenard AJ, Bürck J, Sahin C, Ulrich AS, Landreh M, Pedersen MC, Rheinstädter MC, Pedersen PA, Lindorff-Larsen K, Arleth L, Kragelund BB. Kassem N, et al. Sci Adv. 2021 Jun 30;7(27):eabh3805. doi: 10.1126/sciadv.abh3805. Print 2021 Jun. Sci Adv. 2021. PMID: 34193419 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources