Polyphenols from blueberries modulate inflammation cytokines in LPS-induced RAW264.7 macrophages - PubMed (original) (raw)

Polyphenols from blueberries modulate inflammation cytokines in LPS-induced RAW264.7 macrophages

Anwei Cheng et al. Int J Biol Macromol. 2014 Aug.

Abstract

Polyphenols including 3-glucoside/arabinoside/galactoside-based polymers of delphinidins, petunidins, peonidins, malvidins and cyanidins are one type of biological macromolecules, which are extraordinarily rich in blueberries. Anti-inflammatory activity of blueberry polyphenols (BPPs) was investigated by using lipopolysaccharide (LPS) induced RAW264.7 macrophages. The results showed that BPPs suppressed the gene expression of IL-1β (interleukin-1β), IL-6 and IL-12p35. The inhibition effect on IL-1β and IL-6 mRNA was most obvious at the concentration of 10-200μg/mL BPPs. But the inhibition effect on IL-12p35 mRNA was increased with the increasing concentration of BPPs. When fixed at 100μg/mL BPPs, the most significant inhibition on IL-1β, IL-6 and IL-12p35 mRNA expression was detected at 12-48h. In conclusion, BPPs exhibit anti-inflammation activity by mediating and modulating the balances in pro-inflammatory cytokines of IL-1β, IL-6, and IL-12.

Keywords: Anti-inflammation; Blueberries; Polyphenols.

PubMed Disclaimer

Cited by

Enhancing the Anticancer and Anti-Inflammatory Properties of Curcumin in Combination with Quercetin, for the Prevention and Treatment of Prostate Cancer.
Pellegrino M, Bevacqua E, Frattaruolo L, Cappello AR, Aquaro S, Tucci P. Pellegrino M, et al. Biomedicines. 2023 Jul 18;11(7):2023. doi: 10.3390/biomedicines11072023. Biomedicines. 2023. PMID: 37509660 Free PMC article.
Syringic acid demonstrates an anti-inflammatory effect via modulation of the NF-κB-iNOS-COX-2 and JAK-STAT signaling pathways in methyl cellosolve-induced hepato-testicular inflammation in rats.
Somade OT, Oyinloye BE, Ajiboye BO, Osukoya OA. Somade OT, et al. Biochem Biophys Rep. 2023 May 5;34:101484. doi: 10.1016/j.bbrep.2023.101484. eCollection 2023 Jul. Biochem Biophys Rep. 2023. PMID: 37197735 Free PMC article.
Anti-Inflammatory Effects of Polyphenols from Plum (Prunus salicina Lindl) on RAW264.7 Macrophages Induced by Monosodium Urate and Potential Mechanisms.
Li Y, Deng W, Wu L, Chen S, Zheng Z, Song H. Li Y, et al. Foods. 2023 Jan 5;12(2):254. doi: 10.3390/foods12020254. Foods. 2023. PMID: 36673346 Free PMC article.
Immunomodulatory Activity of Punicalagin, Punicalin, and Ellagic Acid Differs from the Effect of Pomegranate Peel Extract.
Čolić M, Mihajlović D, Bekić M, Marković M, Dragišić B, Tomić S, Miljuš N, Šavikin K, Škrbić R. Čolić M, et al. Molecules. 2022 Nov 15;27(22):7871. doi: 10.3390/molecules27227871. Molecules. 2022. PMID: 36431972 Free PMC article.
Khaya grandifoliola active fraction as a source of therapeutic compounds for Alzheimer's disease treatment: In silico validation of identified compounds.
Owona BA, Njayou FN, Mkounga P, Moundipa PF. Owona BA, et al. In Silico Pharmacol. 2022 Jul 4;10(1):11. doi: 10.1007/s40203-022-00126-0. eCollection 2022. In Silico Pharmacol. 2022. PMID: 35800001 Free PMC article.

Polyphenols from blueberries modulate inflammation cytokines in LPS-induced RAW264.7 macrophages - PubMed (original) (raw)