Effect of a test meal on meal responses of satiation hormones and their association to insulin resistance in obese adolescents - PubMed (original) (raw)

Controlled Clinical Trial

. 2014 Sep;22(9):2047-52.

doi: 10.1002/oby.20805. Epub 2014 Jun 13.

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Controlled Clinical Trial

Effect of a test meal on meal responses of satiation hormones and their association to insulin resistance in obese adolescents

Svetlana Beglinger et al. Obesity (Silver Spring). 2014 Sep.

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Abstract

Objective: The role of gastrointestinal (GI) hormones in the pathophysiology of obesity is unclear, although they are involved in the regulation of satiation and glucose metabolism. To (i) examine glucagon-like peptide 1 (GLP-1), amylin, ghrelin, and glucagon responses to a meal in obese adolescents and to (ii) test which GI peptides are associated with insulin resistance are presented.

Methods: A total of 16 obese (body mass index (BMI) ≥ 97th percentile for age and gender) and 14 control (BMI between 25th and 75th percentiles) adolescents were included. Subjects were instructed to eat a test meal (490 kcal). Plasma samples were collected for hormone and glucose analysis.

Results: Obese adolescents were insulin resistant as expressed by the Homeostasis Model Assessment (HOMA) index and had significantly increased fasting glucagon and amylin levels compared to the control group (P = 0.003 and 0.044, respectively). In response to the meal, the increase in GLP-1 levels was reduced in obese adolescents (P < 0.001). In contrast, amylin secretion was significantly increased in the obese population compared to the control group (P < 0.005).

Conclusions: Obese adolescents have increased fasting glucagon and amylin levels and attenuated post-prandial GLP-1 concentrations compared with the control group. These factors could contribute to the metabolic syndrome.

© 2014 The Obesity Society.

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