ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C - PubMed (original) (raw)
Comparative Study
. 1989 Mar 13;245(1-2):25-9.
doi: 10.1016/0014-5793(89)80184-x.
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- PMID: 2494077
- DOI: 10.1016/0014-5793(89)80184-x
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Comparative Study
ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C
S Cockcroft et al. FEBS Lett. 1989.
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Abstract
Human neutrophils and HL60 cells respond to extracellular ATP by causing exocytotic secretion. Secretion is accompanied by increases in inositol phosphates and a rise in cytosol Ca2+. The responses to ATP are blocked by pertussis toxin pretreatment, indicating the involvement of a guanine nucleotide regulatory protein. Other nucleotides that are active in promoting secretion are ATP gamma S, UTP, ITP and AppNHp, whilst 8-bromo-ATP, AppCH2p, ADP, AMP and adenosine are inactive.
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