Melatonin and melatonin agonist for delirium in the elderly patients - PubMed (original) (raw)
Review
Melatonin and melatonin agonist for delirium in the elderly patients
Dwaipayan Chakraborti et al. Am J Alzheimers Dis Other Demen. 2015 Mar.
Abstract
The objective of this review is to summarize the available data on the use of melatonin and melatonin agonist for the prevention and management of delirium in the elderly patients from randomized controlled trials (RCTs). A systematic search of 5 major databases PubMed, MEDLINE, PsychINFO, Embase, and Cochrane Library was conducted. This search yielded a total of 2 RCTs for melatonin. One study compared melatonin to midazolam, clonidine, and control groups for the prevention and management of delirium in individuals who were pre- and posthip post-hip arthroplasty. The other study compared melatonin to placebo for the prevention of delirium in older adults admitted to an inpatient internal medicine service. Data from these 2 studies indicate that melatonin may have some benefit in the prevention and management of delirium in older adults. However, there is no evidence that melatonin reduces the severity of delirium or has any effect on behaviors or functions in these individuals. Melatonin was well tolerated in these 2 studies. The search for a melatonin agonist for delirium in the elderly patients yielded 1 study of ramelteon. In this study, ramelteon was found to be beneficial in preventing delirium in medically ill individuals when compared to placebo. Ramelteon was well tolerated in this study.
Keywords: delirium; melatonin; melatonin agonist; ramelteon; randomized controlled trials.
© The Author(s) 2014.
Conflict of interest statement
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Similar articles
- Melatonin Receptor Agonists for Delirium Prevention.
Walker CK, Gales MA. Walker CK, et al. Ann Pharmacother. 2017 Jan;51(1):72-78. doi: 10.1177/1060028016665863. Epub 2016 Aug 20. Ann Pharmacother. 2017. PMID: 27539735 Review. - Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis.
Beaucage-Charron J, Rinfret J, Coveney R, Williamson D. Beaucage-Charron J, et al. J Psychosom Res. 2023 Jul;170:111345. doi: 10.1016/j.jpsychores.2023.111345. Epub 2023 May 1. J Psychosom Res. 2023. PMID: 37150157 Review. - Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Maneeton B, Kongsaengdao S, Maneeton N, Likhitsathian S, Woottiluk P, Kawilapat S, Srisurapanont M. Maneeton B, et al. Curr Neuropharmacol. 2022;20(10):1956-1968. doi: 10.2174/1570159X20666220507024219. Curr Neuropharmacol. 2022. PMID: 35524672 Free PMC article. - Melatonergic agents in the prevention of delirium: A network meta-analysis of randomized controlled trials.
Yang CP, Tseng PT, Pei-Chen Chang J, Su H, Satyanarayanan SK, Su KP. Yang CP, et al. Sleep Med Rev. 2020 Apr;50:101235. doi: 10.1016/j.smrv.2019.101235. Epub 2019 Nov 14. Sleep Med Rev. 2020. PMID: 31801100 Review. - Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial.
Oh ES, Leoutsakos JM, Rosenberg PB, Pletnikova AM, Khanuja HS, Sterling RS, Oni JK, Sieber FE, Fedarko NS, Akhlaghi N, Neufeld KJ. Oh ES, et al. Am J Geriatr Psychiatry. 2021 Jan;29(1):90-100. doi: 10.1016/j.jagp.2020.05.006. Epub 2020 May 16. Am J Geriatr Psychiatry. 2021. PMID: 32532654 Free PMC article. Clinical Trial.
Cited by
- Using Machine Learning Algorithms to Predict High-Risk Factors for Postoperative Delirium in Elderly Patients.
Liu Y, Shen W, Tian Z. Liu Y, et al. Clin Interv Aging. 2023 Feb 8;18:157-168. doi: 10.2147/CIA.S398314. eCollection 2023. Clin Interv Aging. 2023. PMID: 36789284 Free PMC article. - Incidence and Risk Factors of Delirium in the Intensive Care Unit: A Prospective Cohort.
Rahimi-Bashar F, Abolhasani G, Manouchehrian N, Jiryaee N, Vahedian-Azimi A, Sahebkar A. Rahimi-Bashar F, et al. Biomed Res Int. 2021 Jan 8;2021:6219678. doi: 10.1155/2021/6219678. eCollection 2021. Biomed Res Int. 2021. PMID: 33506019 Free PMC article. - Delirium in the elderly: A systematic review of pharmacological and non-pharmacological treatments.
Cerveira CCT, Pupo CC, Dos Santos SS, Santos JEM. Cerveira CCT, et al. Dement Neuropsychol. 2017 Jul-Sep;11(3):270-275. doi: 10.1590/1980-57642016dn11-030009. Dement Neuropsychol. 2017. PMID: 29213524 Free PMC article. - Melatonin and the Prevention and Management of Delirium: A Scoping Study.
Choy SW, Yeoh AC, Lee ZZ, Srikanth V, Moran C. Choy SW, et al. Front Med (Lausanne). 2018 Jan 8;4:242. doi: 10.3389/fmed.2017.00242. eCollection 2017. Front Med (Lausanne). 2018. PMID: 29376051 Free PMC article. - Melatonin, temazepam and placebo in hospitalised older patients with sleeping problems (MATCH): a study protocol of randomised controlled trial.
Stenveld F, Bosman S, van Munster BC, Beishuizen SJ, Hempenius L, van der Velde N, Smidt N, de Rooij SE. Stenveld F, et al. BMJ Open. 2019 May 22;9(5):e025514. doi: 10.1136/bmjopen-2018-025514. BMJ Open. 2019. PMID: 31122969 Free PMC article.
References
- Saxena S, Lawley D. Delirium in the elderly: a clinical review. Postgrad Med J. 2009;85 (1006):405–413. - PubMed
- Miller MO. Evaluation and management of delirium in hospitalized older patients. Am Fam Physician. 2008;78 (11):1265–1270. - PubMed
- Siddiqi N, House AO, Holmes JD. Occurrence and outcome of delirium in medical in-patients: a systematic literature review. Age Ageing. 2006;35 (4):350–364. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical