Folate intake and the risk of oral cavity and pharyngeal cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology Consortium - PubMed (original) (raw)
Meta-Analysis
. 2015 Feb 15;136(4):904-14.
doi: 10.1002/ijc.29044. Epub 2014 Jul 7.
Valeria Edefonti, Maria Parpinel, Emanuele Leoncini, Keitaro Matsuo, Renato Talamini, Andrew F Olshan, Jose P Zevallos, Deborah M Winn, Vijayvel Jayaprakash, Kirsten Moysich, Zuo-Feng Zhang, Hal Morgenstern, Fabio Levi, Cristina Bosetti, Karl Kelsey, Michael McClean, Stimson Schantz, Guo-Pei Yu, Paolo Boffetta, Yuan-Chin Amy Lee, Mia Hashibe, Carlo La Vecchia, Stefania Boccia
Affiliations
- PMID: 24974959
- PMCID: PMC4262536
- DOI: 10.1002/ijc.29044
Meta-Analysis
Folate intake and the risk of oral cavity and pharyngeal cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology Consortium
Carlotta Galeone et al. Int J Cancer. 2015.
Abstract
There are suggestions of an inverse association between folate intake and serum folate levels and the risk of oral cavity and pharyngeal cancers (OPCs), but most studies are limited in sample size, with only few reporting information on the source of dietary folate. Our study aims to investigate the association between folate intake and the risk of OPC within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. We analyzed pooled individual-level data from ten case-control studies participating in the INHANCE consortium, including 5,127 cases and 13,249 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated for the associations between total folate intake (natural, fortification and supplementation) and natural folate only, and OPC risk. We found an inverse association between total folate intake and overall OPC risk (the adjusted OR for the highest vs. the lowest quintile was 0.65, 95% CI: 0.43-0.99), with a stronger association for oral cavity (OR = 0.57, 95% CI: 0.43-0.75). A similar inverse association, though somewhat weaker, was observed for folate intake from natural sources only in oral cavity cancer (OR = 0.64, 95% CI: 0.45-0.91). The highest OPC risk was observed in heavy alcohol drinkers with low folate intake as compared to never/light drinkers with high folate (OR = 4.05, 95% CI: 3.43-4.79); the attributable proportion (AP) owing to interaction was 11.1% (95% CI: 1.4-20.8%). Lastly, we reported an OR of 2.73 (95% CI:2.34-3.19) for those ever tobacco users with low folate intake, compared with nevere tobacco users and high folate intake (AP of interaction =10.6%, 95% CI: 0.41-20.8%). Our project of a large pool of case-control studies supports a protective effect of total folate intake on OPC risk.
Keywords: diet; epidemiology; folate intake; oral cancer; risk factor.
© 2014 UICC.
Conflict of interest statement
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Figure 1
References
- Ferlay J, Soerjomataram I, Ervik M, et al., editors. IARC Cancer Base No 10. Lyon, France: International Agency for Research on Cancer; 2013. Globocan 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]
- (AICR) WCRFWaAIfCR. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspectiveed. Washington, DC: American Institute for Cancer Research; 2007. Mouth, pharynx, and larynx; pp. 245–9.
- La Vecchia C, Franceschi S, Levi F, Lucchini F, Negri E. Diet and human oral carcinoma in Europe. Eur J Cancer B Oral Oncol. 1993;29B:17–22. - PubMed
- Winn DM. Diet and nutrition in the etiology of oral cancer. Am J Clin Nutr. 1995;61:437S–45S. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- R01 DA011386/DA/NIDA NIH HHS/United States
- R01 CA078609/CA/NCI NIH HHS/United States
- R01CA078609/CA/NCI NIH HHS/United States
- R21ES011667/ES/NIEHS NIH HHS/United States
- R03CA113157/CA/NCI NIH HHS/United States
- P50 CA090388/CA/NCI NIH HHS/United States
- P30 ES010126/ES/NIEHS NIH HHS/United States
- P50CA090388/CA/NCI NIH HHS/United States
- R03DE016611/DE/NIDCR NIH HHS/United States
- T32CA009142/CA/NCI NIH HHS/United States
- R01CA100679/CA/NCI NIH HHS/United States
- T32 CA009142/CA/NCI NIH HHS/United States
- U01 CA096134/CA/NCI NIH HHS/United States
- ImNIH/Intramural NIH HHS/United States
- R03 CA077954/CA/NCI NIH HHS/United States
- R21 ES011667/ES/NIEHS NIH HHS/United States
- R01CA051845/CA/NCI NIH HHS/United States
- R01 CA100679/CA/NCI NIH HHS/United States
- P30 DK056350/DK/NIDDK NIH HHS/United States
- R01CA061188/CA/NCI NIH HHS/United States
- R03 CA113157/CA/NCI NIH HHS/United States
- R03 DE016611/DE/NIDCR NIH HHS/United States
- R01DA011386/DA/NIDA NIH HHS/United States
- U01CA096134/CA/NCI NIH HHS/United States
- P30ES010126/ES/NIEHS NIH HHS/United States
- R03CA077954/CA/NCI NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical