Kif7 keeps cilia tips in shape - PubMed (original) (raw)

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doi: 10.1038/ncb2997.

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• PMID: 24981634
• DOI: 10.1038/ncb2997

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Kif7 keeps cilia tips in shape

Lotte B Pedersen et al. Nat Cell Biol. 2014 Jul.

Abstract

The kinesin-4 motor protein Kif7 regulates Hedgehog signalling at cilia in mammals by controlling the activity of Gli transcription factors. Kif7 is now found to inhibit microtubule growth to restrict and coordinate the length of axonemal microtubules at the ciliary tip. Such Kif7-mediated organization of the ciliary tip compartment regulates Gli activity and is proposed to be required for correct Hedgehog signalling.

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• The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.
  He M, Subramanian R, Bangs F, Omelchenko T, Liem KF Jr, Kapoor TM, Anderson KV. He M, et al. Nat Cell Biol. 2014 Jul;16(7):663-72. doi: 10.1038/ncb2988. Epub 2014 Jun 22. Nat Cell Biol. 2014. PMID: 24952464 Free PMC article.

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References

1. 1. Dev Cell. 2012 Dec 11;23(6):1167-75 - PubMed
2. 1. Nat Rev Mol Cell Biol. 2013 Jul;14(7):416-29 - PubMed
3. 1. Curr Biol. 2009 Aug 11;19(15):1320-6 - PubMed
4. 1. J Cell Biol. 2012 Jun 11;197(6):789-800 - PubMed
5. 1. Cell. 2012 Apr 13;149(2):371-82 - PubMed

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