Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins - PubMed (original) (raw)

Review

Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins

K Struhl. Trends Biochem Sci. 1989 Apr.

Abstract

Four distinct structural motifs have been proposed for the DNA-binding domains of eukaryotic transcriptional regulatory proteins; the helix-turn-helix, two kinds of zinc finger, and the leucine zipper. Within each structural motif, there are often families of related proteins that recognize similar DNA sequences and are conserved throughout the eukaryotic kingdom. However, the processes of transcriptional activation and repression appear to be independent of the specific type of protein-DNA interaction.

PubMed Disclaimer

Similar articles

• Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function.
  Blumberg H, Eisen A, Sledziewski A, Bader D, Young ET. Blumberg H, et al. Nature. 1987 Jul 30-Aug 5;328(6129):443-5. doi: 10.1038/328443a0. Nature. 1987. PMID: 3112579
• Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA.
  Weiss MA, Ellenberger T, Wobbe CR, Lee JP, Harrison SC, Struhl K. Weiss MA, et al. Nature. 1990 Oct 11;347(6293):575-8. doi: 10.1038/347575a0. Nature. 1990. PMID: 2145515
• Eukaryotic transcription factors.
  Latchman DS. Latchman DS. Biochem J. 1990 Sep 1;270(2):281-9. doi: 10.1042/bj2700281. Biochem J. 1990. PMID: 2119171 Free PMC article. Review. No abstract available.
• Regulation of transcription in eukaryotes by DNA-binding proteins.
  Krajewska WM. Krajewska WM. Int J Biochem. 1992 Dec;24(12):1885-98. doi: 10.1016/0020-711x(92)90284-8. Int J Biochem. 1992. PMID: 1473601 Review.

Cited by

• HD-Zip proteins: members of an Arabidopsis homeodomain protein superfamily.
  Schena M, Davis RW. Schena M, et al. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3894-8. doi: 10.1073/pnas.89.9.3894. Proc Natl Acad Sci U S A. 1992. PMID: 1349174 Free PMC article.
• Oxygen regulated gene expression in Escherichia coli: control of anaerobic respiration by the FNR protein.
  Unden G, Trageser M. Unden G, et al. Antonie Van Leeuwenhoek. 1991 Feb;59(2):65-76. doi: 10.1007/BF00445650. Antonie Van Leeuwenhoek. 1991. PMID: 1854188 Review.
• The GCN4 bZIP can bind to noncognate gene regulatory sequences.
  Fedorova AV, Chan IS, Shin JA. Fedorova AV, et al. Biochim Biophys Acta. 2006 Jul;1764(7):1252-9. doi: 10.1016/j.bbapap.2006.04.009. Epub 2006 May 4. Biochim Biophys Acta. 2006. PMID: 16784907 Free PMC article.
• The bZIP targets overlapping DNA subsites within a half-site, resulting in increased binding affinities.
  Chan IS, Shahravan SH, Fedorova AV, Shin JA. Chan IS, et al. Biochemistry. 2008 Sep 9;47(36):9646-52. doi: 10.1021/bi800355t. Epub 2008 Aug 15. Biochemistry. 2008. PMID: 18702507 Free PMC article.
• SOX genes: architects of development.
  Prior HM, Walter MA. Prior HM, et al. Mol Med. 1996 Jul;2(4):405-12. Mol Med. 1996. PMID: 8827711 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database