Genetic interactions of the suppressor 2 of zeste region genes - PubMed (original) (raw)
Genetic interactions of the suppressor 2 of zeste region genes
P N Adler et al. Dev Genet. 1989.
Abstract
A wide variety of gain of function mutations have been induced in the Posterior Sex Comb (Psc)--Aristapedioid (Arp)--Suppressor 2 of zeste (Su(z)2) region of the second chromosome of Drosophila. This region contains at least three apparently related genes, two of which we have been studying. Psc1 has previously been used to identify Psc as a Pc group gene; however, it is a complex mutation with both gain and loss of function character. We report here that the Pc group character of Psc is not due to a gain of function and presumably reflects the function of the wild-type gene. We also provide evidence for a maternal function for Psc, as well as the neighboring Su(z)2 gene. Su(z)2 does not appear to be a Pc group gene as it does not act in a synergistic fashion with other Pc group genes in promoting posteriorly directed transformations. However, we have found that mutations in Su(z)2 do interact in a variety of interesting ways with mutations in Pc group genes.
Similar articles
- Directed overexpression of suppressor 2 of zeste and Posterior Sex Combs results in bristle abnormalities in Drosophila melanogaster.
Sharp EJ, Martin EC, Adler PN. Sharp EJ, et al. Dev Biol. 1994 Feb;161(2):379-92. doi: 10.1006/dbio.1994.1039. Dev Biol. 1994. PMID: 8313990 - Phenotypic consequences and genetic interactions of a null mutation in the Drosophila Posterior Sex Combs gene.
Adler PN, Martin EC, Charlton J, Jones K. Adler PN, et al. Dev Genet. 1991;12(5):349-61. doi: 10.1002/dvg.1020120504. Dev Genet. 1991. PMID: 1806331 - [Suppressor mutation, interacting with the white alleles of Drosophila melanogaster].
Khatypova MA, Gerasimova TI. Khatypova MA, et al. Genetika. 1992 May;28(5):176-8. Genetika. 1992. PMID: 1639257 Russian.
Cited by
- Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.
Dardalhon-Cuménal D, Deraze J, Dupont CA, Ribeiro V, Coléno-Costes A, Pouch J, Le Crom S, Thomassin H, Debat V, Randsholt NB, Peronnet F. Dardalhon-Cuménal D, et al. PLoS Genet. 2018 Jul 11;14(7):e1007498. doi: 10.1371/journal.pgen.1007498. eCollection 2018 Jul. PLoS Genet. 2018. PMID: 29995890 Free PMC article. - The three-dimensional architecture of Hox cluster silencing.
Ferraiuolo MA, Rousseau M, Miyamoto C, Shenker S, Wang XQ, Nadler M, Blanchette M, Dostie J. Ferraiuolo MA, et al. Nucleic Acids Res. 2010 Nov;38(21):7472-84. doi: 10.1093/nar/gkq644. Epub 2010 Jul 25. Nucleic Acids Res. 2010. PMID: 20660483 Free PMC article. - Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains.
Emmons RB, Genetti H, Filandrinos S, Lokere J, Wu CT. Emmons RB, et al. Genetics. 2009 Aug;182(4):999-1013. doi: 10.1534/genetics.108.097360. Epub 2009 Jun 15. Genetics. 2009. PMID: 19528329 Free PMC article. - Polycomb group protein Suppressor 2 of zeste is a functional homolog of Posterior Sex Combs.
Lo SM, Ahuja NK, Francis NJ. Lo SM, et al. Mol Cell Biol. 2009 Jan;29(2):515-25. doi: 10.1128/MCB.01044-08. Epub 2008 Nov 3. Mol Cell Biol. 2009. PMID: 18981224 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous