Changing the core of transcription - PubMed (original) (raw)

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Changing the core of transcription

Katherine A Jones. Elife. 2014.

Abstract

Different members of the TAF family of proteins work in differentiated cells, such as motor neurons or brown fat cells, to control the expression of genes that are specific to each cell type.

Keywords: TBP-associated factor TAF; motor neurons; neuronal enhancers; neuronal gene expression; stem cells; transcription factors.

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Conflict of interest statement

Competing interests:The author declares that no competing interests exist.

Figures

Figure 1.. TATA-binding protein associated factors (TAFs) regulate transcription in specific cell types.

TAF3, for example, works with another transcription factor to regulate the expression of genes that are critical for the differentiation of the endoderm in the early embryo (Liu et al., 2011). TAF3 also forms a complex with the TATA-related factor, TRF3, to regulate Myogenin and other muscle-specific genes to form myotubes (Deato et al., 2008). TAF7L interacts with another transcription factor to activate genes involved in the formation of adipocytes (‘fat cells’) and adipose tissue (Zhou et al., 2013; Zhou et al., 2014). Finally, TAF9B is a key regulator of transcription in motor neurons (Herrera et al., 2014). The names of some of the genes regulated by the TAFs are shown in brackets.

Comment on

Core promoter factor TAF9B regulates neuronal gene expression.
Herrera FJ, Yamaguchi T, Roelink H, Tjian R. Herrera FJ, et al. Elife. 2014 Jul 8;3:e02559. doi: 10.7554/eLife.02559. Elife. 2014. PMID: 25006164 Free PMC article.

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Changing the core of transcription - PubMed (original) (raw)