Structural and functional analyses of bovine and porcine intestinal heparins confirm they are different drugs - PubMed (original) (raw)

Review

. 2014 Nov;19(11):1801-1807.

doi: 10.1016/j.drudis.2014.07.004. Epub 2014 Jul 12.

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Review

Structural and functional analyses of bovine and porcine intestinal heparins confirm they are different drugs

Gustavo R C Santos et al. Drug Discov Today. 2014 Nov.

Abstract

Anticoagulant heparins are mostly obtained from porcine intestine. Occasionally they are also obtained from bovine intestine. Structural and functional analyses of pharmaceutical-grade heparins from these two sources using multiple methods such as NMR spectroscopy, in vitro and in vivo assays of the anticoagulant, antithrombotic and bleeding effects, complemented by fractionation on anion exchange chromatography, confirm they are different drugs. Although bovine heparin is more heterogeneous and less sulfated, heparins from both sources are overall made of a similar mixture of fractions, however with different proportions. Therefore, high-anticoagulant composites from bovine origin, similar to porcine counterparts, can be properly obtained.

Copyright © 2014 Elsevier Ltd. All rights reserved.

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