Indomethacin modulation of load-related stimulation of new bone formation in vivo - PubMed (original) (raw)
Indomethacin modulation of load-related stimulation of new bone formation in vivo
M J Pead et al. Calcif Tissue Int. 1989 Jul.
Abstract
The capacity of bone to organize and reorganize its structure in response to changing mechanical demands is well recognized. However, the mechanism by which the changing mechanical environment is detected, and the means by which this information is translated into a stimulus for structural modification, are not understood. A group of substances suggested to be involved in the initial transduction of strain information are the prostaglandins. In this experiment we used a single period of dynamic loading to stimulate an adaptive osteogenic response in vivo. Loading was performed in the presence and absence of indomethacin. Measurements of the periosteum 5 days after loading showed that the presence of indomethacin at the time of loading reduced the osteogenic response. Though consistent with the hypothesis that prostaglandins are involved in the initial transduction of tissue strain into a biochemical response, this result is not sufficient to demonstrate this conclusively because reduced prostaglandin levels during the 24 hours immediately after the period of loading may affect many other points in the cascade of events between strain transduction and adaptive new bone formation. Furthermore, indomethacin at the relatively high levels we used (40 mg/kg) may have effects other than those on prostaglandin synthesis.
Similar articles
- Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation.
Chow JW, Chambers TJ. Chow JW, et al. Am J Physiol. 1994 Aug;267(2 Pt 1):E287-92. doi: 10.1152/ajpendo.1994.267.2.E287. Am J Physiol. 1994. PMID: 8074209 - Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading.
Pead MJ, Skerry TM, Lanyon LE. Pead MJ, et al. J Bone Miner Res. 1988 Dec;3(6):647-56. doi: 10.1002/jbmr.5650030610. J Bone Miner Res. 1988. PMID: 3251399 - Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo.
Forwood MR. Forwood MR. J Bone Miner Res. 1996 Nov;11(11):1688-93. doi: 10.1002/jbmr.5650111112. J Bone Miner Res. 1996. PMID: 8915776 - Microgravity and bone cell mechanosensitivity.
Klein-Nulend J, Bacabac RG, Veldhuijzen JP, Van Loon JJ. Klein-Nulend J, et al. Adv Space Res. 2003;32(8):1551-9. doi: 10.1016/S0273-1177(03)90395-4. Adv Space Res. 2003. PMID: 15000126 Review. - Mechano-reception in osteoblast-like cells.
Jones D, Leivseth G, Tenbosch J. Jones D, et al. Biochem Cell Biol. 1995 Jul-Aug;73(7-8):525-34. doi: 10.1139/o95-058. Biochem Cell Biol. 1995. PMID: 8703423 Review.
Cited by
- Emerging evidence that adaptive bone formation inhibition by non-steroidal anti-inflammatory drugs increases stress fracture risk.
Staab JS, Kolb AL, Tomlinson RE, Pajevic PD, Matheny RW Jr, Hughes JM. Staab JS, et al. Exp Biol Med (Maywood). 2021 May;246(9):1104-1111. doi: 10.1177/1535370221993098. Epub 2021 Feb 27. Exp Biol Med (Maywood). 2021. PMID: 33641442 Free PMC article. Review. - Nonsteroidal Anti-Inflammatory Drug Prescriptions Are Associated With Increased Stress Fracture Diagnosis in the US Army Population.
Hughes JM, McKinnon CJ, Taylor KM, Kardouni JR, Bulathsinhala L, Guerriere KI, Popp KL, Bouxsein ML, Proctor SP, Matheny RW Jr. Hughes JM, et al. J Bone Miner Res. 2019 Mar;34(3):429-436. doi: 10.1002/jbmr.3616. Epub 2018 Dec 10. J Bone Miner Res. 2019. PMID: 30352135 Free PMC article. - Bone Research Society, Annual Meeting 2017 Proceedings. 25-27 June 2017, Bristol, UK.
[No authors listed] [No authors listed] J Musculoskelet Neuronal Interact. 2018 Mar 1;18(1):108-151. J Musculoskelet Neuronal Interact. 2018. PMID: 29504586 Free PMC article. No abstract available. - The Role of the Osteocyte in Bone and Nonbone Disease.
Bonewald LF. Bonewald LF. Endocrinol Metab Clin North Am. 2017 Mar;46(1):1-18. doi: 10.1016/j.ecl.2016.09.003. Epub 2016 Dec 12. Endocrinol Metab Clin North Am. 2017. PMID: 28131126 Free PMC article. Review. - Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training.
Sherk VD, Carpenter RD, Giles ED, Higgins JA, Oljira RM, Johnson GC, Mills S, Maclean PS. Sherk VD, et al. Med Sci Sports Exerc. 2017 May;49(5):888-895. doi: 10.1249/MSS.0000000000001194. Med Sci Sports Exerc. 2017. PMID: 28079706 Free PMC article.
References
- Am J Anat. 1982 Dec;165(4):373-84 - PubMed
- Nature. 1978 Dec 21-28;276(5690):841-2 - PubMed
- J Bone Miner Res. 1986 Jun;1(3):243-9 - PubMed
- Calcif Tissue Int. 1984;36 Suppl 1:S82-5 - PubMed
- J Bone Joint Surg Am. 1984 Mar;66(3):397-402 - PubMed