The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells - PubMed (original) (raw)

The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells

Y Shirakata et al. Jpn J Cancer Res. 1989 Jul.

Abstract

To examine the transforming potential of the X gene product of hepatitis B virus (HBV), the X-gene-containing region (referred to as the HBx region) was introduced into mouse NIH3T3 cells. Each transformed cell line expressed X-coding mRNA at a different level. A positive correlation was found between the level of X-coding mRNA and the saturation density of the cells. The HBx-transformed cell lines exhibited X protein production and tumor formation in nude mice. The function of HBV in oncogenesis may involve the continuous expression of the X-gene-coded product in the HBV DNA-integrated cells.

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References

1. ) Tiollais , P. , Pourcel , C. and Dejean , A.The hepatitis B virus . Nature , 317 , 489 – 495 ( 1985. ). - PubMed
1. ) Dejean , A. , Sonigo , P. , Wain‐Hobson , S. and Tiollais , P.Sepecific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11‐base‐pair direct repeat . Proc. Natl. Acad. Sci. USA , 81 , 5350 – 5354 ( 1984. ). - PMC - PubMed
1. ) Mizusawa , H. , Taira , M. , Yaginuma , K. , Kobayashi , M. , Yoshida , E. and Koike , K.Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma derived cell line huSP . Proc. Natl. Acad. Sci. USA , 82 , 208 – 212 ( 1985. ). - PMC - PubMed
1. ) Moriarty , A. M. , Alexander , H. , Lerner , R. A. and Thornton , G. B.Antibodies to peptides detect new hepatitis B antigens: serological correlation with hepatocellular carcinoma . Science , 227 , 429 – 433 ( 1985. ). - PubMed
1. ) Kay , A. , Mandart , E. , Trepo , C. and Galibert , F.The HBV HBx gene expressed in E. coli is recognised by sera from hepatitis patients . EMBO J. , 4 , 1287 – 1292 ( 1985. ). - PMC - PubMed

The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells - PubMed (original) (raw)