Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon? - PubMed (original) (raw)

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doi: 10.1038/ki.2014.24.

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• PMID: 25079019
• DOI: 10.1038/ki.2014.24

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Vitamin K and cardiovascular calcification in CKD: is patient supplementation on the horizon?

Maurizio Gallieni et al. Kidney Int. 2014 Aug.

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Abstract

The vitamin K-dependent proteins (VKDPs) matrix Gla protein and osteocalcin protect from cardiovascular calcifications and bone fractures. A vitamin K recycling system maintains sufficient vitamin K levels for activation of VKDPs through γ-glutamyl carboxylase (GGCX). Kaesler et al. demonstrate that uremia per se can interfere with GGCX activity, contributing to vitamin K deficiency in chronic kidney disease and opening the path to the clinical use of vitamin K, currently tested in randomized trials.

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• Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation.
  Kaesler N, Magdeleyns E, Herfs M, Schettgen T, Brandenburg V, Fliser D, Vermeer C, Floege J, Schlieper G, Krüger T. Kaesler N, et al. Kidney Int. 2014 Aug;86(2):286-93. doi: 10.1038/ki.2013.530. Epub 2014 Jan 15. Kidney Int. 2014. PMID: 24429407

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