Peritoneal protein clearance rather than faster transport status determines outcomes in peritoneal dialysis patients - PubMed (original) (raw)

Peritoneal protein clearance rather than faster transport status determines outcomes in peritoneal dialysis patients

Gayathri Rajakaruna et al. Perit Dial Int. 2015 Mar-Apr.

Abstract

Faster peritoneal transport has been associated with an increased risk of therapy failure and patient mortality. However, faster transport can the result of many factors. Peritoneal protein clearance (PPC) has been proposed to distinguish faster peritoneal transport attributable to inflammatory conditions, as protein clearance reflects large-pore flow, which increases during inflammation. We followed a cohort of 300 peritoneal dialysis patients, and after adjustments for age and comorbidity, higher PPC was associated with increased risk of death (hazard ratio: 1.81; 95% confidence interval: 1.11 to 2.95), even after patients underwent transplantation or transferred to hemodialysis.

Keywords: Bioimpedance; extracellular fluid; fast transporter; peritoneal protein loss; survival.

Copyright © 2015 International Society for Peritoneal Dialysis.

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Figures

Figure 1 —

Figure 1 —

Kaplan-Meir survival estimates for the study patients, by peritoneal protein clearance (PPC) and extracellular water-to-total body water ratio (ECW/TBW). Adjusted to age 57 and a Davies comorbidity score (15) of zero.

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