Incidence, severity, and mortality of post-ERCP pancreatitis: a systematic review by using randomized, controlled trials - PubMed (original) (raw)
Review
. 2015 Jan;81(1):143-149.e9.
doi: 10.1016/j.gie.2014.06.045. Epub 2014 Aug 1.
Affiliations
- PMID: 25088919
- DOI: 10.1016/j.gie.2014.06.045
Review
Incidence, severity, and mortality of post-ERCP pancreatitis: a systematic review by using randomized, controlled trials
Bharati Kochar et al. Gastrointest Endosc. 2015 Jan.
Abstract
Background: Data regarding the incidence and severity of post-ERCP pancreatitis (PEP) are primarily from nonrandomized studies.
Objective: To determine the incidence, severity, and mortality of PEP from a systematic review of the placebo or no-stent arms of randomized, controlled trials (RCTs).
Design: MEDLINE, EMBASE, and Cochrane databases were searched to identify RCTs evaluating the efficacy of drugs and/or pancreatic stents to prevent PEP.
Setting: Systematic review of patients enrolled in RCTs evaluating agents for PEP prophylaxis.
Patients: Patients in the placebo or no-stent arms of the RCTs
Intervention: ERCP.
Main outcome measurements: Incidence, severity, and mortality of PEP.
Results: There were 108 RCTs with 13,296 patients in the placebo or no-stent arms. Overall, the PEP incidence was 9.7% and the mortality rate was 0.7%. Severity of PEP was reported for 8857 patients: 5.7%, 2.6%, and 0.5% of cases were mild, moderate, and severe, respectively. The incidence of PEP in 2345 high-risk patients was 14.7% and the severity of PEP was mild, moderate, and severe in 8.6%, 3.9%, and 0.8%, respectively, with a 0.2% mortality rate. The incidence of PEP was 13% in North American RCTs compared with 8.4% in European and 9.9% in Asian RCTs. ERCPs conducted before and after 2000 had a PEP incidence of 7.7% and 10%, respectively.
Limitations: Difference in PEP risk among patients in the included RCTs.
Conclusion: The incidence of PEP and severe PEP is similar in high-risk patients and the overall cohort. Discrepancies in the incidence of PEP across geographic regions require further study.
Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
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