Progression to development of lymphoma in the thymus of AKR mice treated neonatally with SL 3-3 virus - PubMed (original) (raw)
. 1989 Dec;17(11):1116-21.
Affiliations
- PMID: 2511036
Progression to development of lymphoma in the thymus of AKR mice treated neonatally with SL 3-3 virus
E F Hays et al. Exp Hematol. 1989 Dec.
Abstract
All AKR mice develop thymic lymphoma between 60 and 90 days of age after neonatal treatment with the oncogenic retrovirus SL 3-3. At 40-50 days of age, in the normal-sized thymus of virus-treated mice, cells appear that produce lymphoma when inoculated intrathymically but not when inoculated s.c. These cells are designated as thymus-dependent (TD) lymphoma cells. TD cells progress to cells that form tumors after both intrathymic and s.c. inoculation; these are designated as thymus-independent (TI) lymphoma cells. In this report, we show that the TD and TI cells can be distinguished as two distinct cell populations. Experiments show that the TD cells reside within the immature CD4- CD8- thymocyte population of the virus-treated mice. In addition, we also show that CD4- CD8- thymocytes from SL 3-3 virus-treated mice do not mature in fetal thymic stromal rudiments. Using three-color flow cytometry to trace maturation of CD4- CD8- thymocytes after intrathymic inoculation into irradiated syngeneic hosts, disregulated thymocyte maturation of this population from virus-treated mice is demonstrated. Thus, altered maturation of and the appearance of TD lymphoma cells in, the most immature population of thymocytes appears to be a first step in a multistep process of thymic lymphomagenesis caused by SL 3-3 virus.
Similar articles
- Development of lymphoma in the thymus of AKR mice treated with the lymphomagenic virus SL 3-3.
Hays EF, Bristol GC, McDougall S, Klotz JL, Kronenberg M. Hays EF, et al. Cancer Res. 1989 Aug 1;49(15):4225-30. Cancer Res. 1989. PMID: 2545338 - Development of virus-accelerated thymic lymphoma in AKR mice.
Kato A, Hays EF. Kato A, et al. J Natl Cancer Inst. 1985 Sep;75(3):491-7. J Natl Cancer Inst. 1985. PMID: 3861900 - Phenotypic characterization of thymic prelymphoma cells of B10 mice treated with split-dose irradiation.
Muto M, Kubo E, Kamisaku H, Sado T. Muto M, et al. J Immunol. 1990 Feb 1;144(3):849-53. J Immunol. 1990. PMID: 2104913 - Cellular events in radiation-induced lymphomagenesis.
Boniver J, Humblet C, Rongy AM, Delvenne C, Delvenne P, Greimers R, Thiry A, Courtoy R, Defresne MP. Boniver J, et al. Int J Radiat Biol. 1990 Apr;57(4):693-8. doi: 10.1080/09553009014550861. Int J Radiat Biol. 1990. PMID: 1969901 Review.
Cited by
- A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.
Glud SZ, Sørensen AB, Andrulis M, Wang B, Kondo E, Jessen R, Krenacs L, Stelkovics E, Wabl M, Serfling E, Palmetshofer A, Pedersen FS. Glud SZ, et al. Blood. 2005 Nov 15;106(10):3546-52. doi: 10.1182/blood-2005-02-0493. Epub 2005 Jul 28. Blood. 2005. PMID: 16051745 Free PMC article. - Disruption of hematopoiesis and thymopoiesis in the early premalignant stages of infection with SL3-3 murine leukemia virus.
Rulli K, Lenz J, Levy LS. Rulli K, et al. J Virol. 2002 Mar;76(5):2363-74. doi: 10.1128/jvi.76.5.2363-2374.2002. J Virol. 2002. PMID: 11836414 Free PMC article. - Mink cell focus-forming murine leukemia virus infection induces apoptosis of thymic lymphocytes.
Yoshimura FK, Wang T, Yu F, Kim HR, Turner JR. Yoshimura FK, et al. J Virol. 2000 Sep;74(17):8119-26. doi: 10.1128/jvi.74.17.8119-8126.2000. J Virol. 2000. PMID: 10933722 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Molecular Biology Databases
Research Materials