Smooth muscle cell phenotypic switch: implications for foam cell formation - PubMed (original) (raw)

Review

Smooth muscle cell phenotypic switch: implications for foam cell formation

Chiraz Chaabane et al. Curr Opin Lipidol. 2014 Oct.

Abstract

Purpose of review: It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant number of foam cells as well. During atherosclerotic plaque formation, SMCs switch from a contractile to a synthetic phenotype. The contribution of this process to foam cell formation is still not well understood.

Recent findings: It has been confirmed that a large proportion of foam cells in human atherosclerotic plaques and in experimental intimal thickening arise from SMCs. SMC-derived foam cells express receptors involved in ox-LDL uptake and HDL reverse transport. In-vitro studies show that treatment of SMCs with ox-LDL induces typical foam-cell formation; this process is associated with a transition of SMCs toward a synthetic phenotype.

Summary: This review summarizes data regarding the phenotypic switch of arterial SMCs within atherosclerotic lesion and their contribution to intimal foam cell formation.

PubMed Disclaimer

Cited by

Transplantation of Autologous Bone Marrow Mononuclear Cells Regulates Inflammation in a Rabbit Model of Carotid Artery Atherosclerosis.
Cui K, Wang M, Yu L, Ren X, Cui H, Yu XF, Hou S, Fu C, Wang J. Cui K, et al. J Vasc Res. 2016;53(3-4):196-205. doi: 10.1159/000449201. Epub 2016 Oct 28. J Vasc Res. 2016. PMID: 27788500 Free PMC article.
Calcium-Binding Protein S100A4 Is Upregulated in Carotid Atherosclerotic Plaques and Contributes to Expansive Remodeling.
Nagata M, Minami M, Yoshida K, Yang T, Yamamoto Y, Takayama N, Ikedo T, Hayashi K, Miyata T, Yokode M, Miyamoto S. Nagata M, et al. J Am Heart Assoc. 2020 Sep 15;9(18):e016128. doi: 10.1161/JAHA.120.016128. Epub 2020 Sep 11. J Am Heart Assoc. 2020. PMID: 32914661 Free PMC article.
Nanobiotechnology approaches for cardiovascular diseases: site-specific targeting of drugs and nanoparticles for atherothrombosis.
Liu H, Pietersz G, Peter K, Wang X. Liu H, et al. J Nanobiotechnology. 2022 Feb 8;20(1):75. doi: 10.1186/s12951-022-01279-y. J Nanobiotechnology. 2022. PMID: 35135581 Free PMC article. Review.
Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis.
Meng Q, Pu L, Luo X, Wang B, Li F, Liu B. Meng Q, et al. Front Physiol. 2020 Oct 19;11:564604. doi: 10.3389/fphys.2020.564604. eCollection 2020. Front Physiol. 2020. PMID: 33192561 Free PMC article. Review.
Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets.
Ramji DP, Davies TS. Ramji DP, et al. Cytokine Growth Factor Rev. 2015 Dec;26(6):673-85. doi: 10.1016/j.cytogfr.2015.04.003. Epub 2015 May 12. Cytokine Growth Factor Rev. 2015. PMID: 26005197 Free PMC article. Review.

Smooth muscle cell phenotypic switch: implications for foam cell formation - PubMed (original) (raw)