Inflammation in diabetic kidney disease - PubMed (original) (raw)

Review

Inflammation in diabetic kidney disease

Patricia M García-García et al. World J Diabetes. 2014.

Abstract

Diabetes mellitus entails significant health problems worldwide. The pathogenesis of diabetes is multifactorial, resulting from interactions of both genetic and environmental factors that trigger a complex network of pathophysiological events, with metabolic and hemodynamic alterations. In this context, inflammation has emerged as a key pathophysiology mechanism. New pathogenic pathways will provide targets for prevention or future treatments. This review will focus on the implications of inflammation in diabetes mellitus, with special attention to inflammatory cytokines.

Keywords: Cytokines; Diabetes; Diabetic kidney disease; Diabetic nephropathy; Inflammation; Oxidative stress.

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Figures

Figure 1

Figure 1

Schematic representation of inflammatory-mediated renal injury in diabetic kidney disease. DM: Diabetes mellitus; NFκB: Nuclear factor κB; DKD: Diabetic kidney disease; JAK/STAT: Janus kinase/signal transducers and activators of transcription.

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