Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun - PubMed (original) (raw)

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

R Chiu et al. Cell. 1989.

Abstract

c-Jun, Jun-B, and Jun-D proteins bind to the TPA response element (TRE) either as homodimers or as Jun-Fos heterodimers. We demonstrate that c-Jun and Jun-B nevertheless differ markedly in their ability to activate AP-1 responsive genes. c-Jun is an efficient activator of the c-jun and collagenase promoters, which contain a single TRE; Jun-B is not. Furthermore, Jun-B inhibits activation of these promoters by c-Jun. On the other hand, like c-Jun, Jun-B is an efficient activator of constructs containing multimeric TREs. Using chimeric proteins, we show that the distinct behavior of c-Jun and Jun-B is due to differences in their activation domains. Trans-activation by Jun-B depends on cooperative interactions between adjacently bound factors, while activation by c-Jun does not require such interactions. This differential behavior greatly expands the regulatory potential of the Jun family.

PubMed Disclaimer

Cited by

Identification and functional characterisation of the cellular activating transcription factor 43 (ATF-43) protein.
Hurst HC, Totty NF, Jones NC. Hurst HC, et al. Nucleic Acids Res. 1991 Sep 11;19(17):4601-9. doi: 10.1093/nar/19.17.4601. Nucleic Acids Res. 1991. PMID: 1653949 Free PMC article.
A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.
Nakayama K, Shimizu H, Mitomo K, Watanabe T, Okamoto S, Yamamoto K. Nakayama K, et al. Mol Cell Biol. 1992 Apr;12(4):1736-46. doi: 10.1128/mcb.12.4.1736-1746.1992. Mol Cell Biol. 1992. PMID: 1372388 Free PMC article.
The effect of tumor necrosis factor-alpha and cAMP on induction of AP-1 activity in MA-10 tumor Leydig cells.
Li X, Hales KH, Watanabe G, Lee RJ, Pestell RG, Hales DB. Li X, et al. Endocrine. 1997 Jun;6(3):317-24. doi: 10.1007/BF02820509. Endocrine. 1997. PMID: 9368689
Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-κB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells.
Dyshlovoy SA, Fedorov SN, Shubina LK, Kuzmich AS, Bokemeyer C, Keller-von Amsberg G, Honecker F. Dyshlovoy SA, et al. Biomed Res Int. 2014;2014:469309. doi: 10.1155/2014/469309. Epub 2014 Jul 23. Biomed Res Int. 2014. PMID: 25215281 Free PMC article.
CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies.
Wang D, Prager BC, Gimple RC, Aguilar B, Alizadeh D, Tang H, Lv D, Starr R, Brito A, Wu Q, Kim LJY, Qiu Z, Lin P, Lorenzini MH, Badie B, Forman SJ, Xie Q, Brown CE, Rich JN. Wang D, et al. Cancer Discov. 2021 May;11(5):1192-1211. doi: 10.1158/2159-8290.CD-20-1243. Epub 2020 Dec 16. Cancer Discov. 2021. PMID: 33328215 Free PMC article.

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun - PubMed (original) (raw)