Finding the missing link between the unfolded protein response and O-GlcNAcylation in the heart - PubMed (original) (raw)

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Finding the missing link between the unfolded protein response and O-GlcNAcylation in the heart

Christopher C Glembotski. Circ Res. 2014.

Abstract

The ER stress-inducible transcription factor, x-box binding protein 1 (XBP1), which enhances protein glycosylation in the endoplasmic reticulum (ER), was shown to also enhance protein glycosylation outside the ER, via a process called O-GlcNAcylation, which protected the heart from ischemia/reperfusion damage.

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Figure

(A) XBP1 is the Missing Link between the UPR and O-GlcNAcylation. The contributions made by Wang et al are shown in blue. (B)Proteins are glycosylated in different cell compartments. (C) A key substrate for O-GlcNAcylation, which is used by the enzyme OGT (O-GlcNAc transferase), is UDP-GlcNAc (uridine diphosphate N-acetyl glucosamine).(D) UDP-GlcNAc is generated by the hexose biosynthetic pathway (HBP). O-GlcNAc groups can be removed from proteins by OGA (O-GlcNAcase). The contributions made by Wang et al are shown in blue.

Comment on

• Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway.
  Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PPA, Ferdous A, Gillette TG, Scherer PE, Hill JA. Wang ZV, et al. Cell. 2014 Mar 13;156(6):1179-1192. doi: 10.1016/j.cell.2014.01.014. Cell. 2014. PMID: 24630721 Free PMC article.

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