Intervening in ageing to prevent the diseases of ageing - PubMed (original) (raw)
Intervening in ageing to prevent the diseases of ageing
Linda Partridge. Trends Endocrinol Metab. 2014 Nov.
Free article
Abstract
Increases in human lifespan worldwide have revealed that advancing age is the predominant risk factor for major life-threatening diseases. Recent work has shown that ageing in diverse animals, including humans, is malleable to specific types of genetic mutation, diet, and drugs that can extend lifespan and improve health during ageing. These findings point to the prospect of broad-spectrum preventive medicine for the diseases of ageing based on intervention in relevant aspects of the ageing process itself.
Keywords: ageing; ageing-related disease; insulin/insulin-like growth factor and TOR signalling.
Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
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