Effects of valproic acid in combination with S-1 on advanced pancreatobiliary tract cancers: clinical study phases I/II - PubMed (original) (raw)

Clinical Trial

. 2014 Sep;34(9):5187-91.

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Clinical Trial

Effects of valproic acid in combination with S-1 on advanced pancreatobiliary tract cancers: clinical study phases I/II

Shuichi Iwahashi et al. Anticancer Res. 2014 Sep.

Abstract

Background/aim: Pancreatobiliary tract cancers are amongst the most aggressive human cancers. Histone deacetylase (HDAC) is well-known to be associated with tumorigenesis through epigenetic regulation and its inhibitors (HDACIs) induce differentiation and apoptosis of tumor cells. We conducted a clinical trial of combination therapy using valproic acid (VPA, a HDACI) and S-1, which is an oral fluoropyrimidine derivative consisting of 5-fluorouracil.

Patients and methods: Patients with advanced pancreatobiliary tract cancers were eligible for this clinical trial. Twelve patients, in whom a curative operation was not feasible, were enrolled in the study. Patients received S-1 orally at a daily dose of 80 mg/m(2) for 28 days, followed by a 14-day recovery period. They also received VPA orally at a total daily dose of 15 mg/kg, twice daily.

Results: One patient had partial response (PR); ten patients were recorded with stable disease (SD); and one patient showed progressive disease (PD). Eight patients had clinically significant drug-related adverse events. The most frequent adverse events were platelet depletion and fatigue. Grade 3/4 adverse events, including anemia and platelet depletion, were observed. Significant increases in blood concentrations of VPA were confirmed 2 and 4 weeks after VPA administration.

Conclusion: Combination therapy of VPA and S-1 for patients with pancreatobiliary tract cancers had a manageable safety profile and preliminary antitumor activity.

Keywords: Pancreatic cancer; cholangiocarcinoma; clinical trial; histone deacetylase (HDAC); histone deacetylase inhibitor (HDACI); valproic acid (VPA).

Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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