Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes - PubMed (original) (raw)
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Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes
Alessandra Puddu et al. Mediators Inflamm. 2014.
Abstract
In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.
Figures
Figure 1
SCFAs improve metabolic functions in T2D. SCFAs were shown to affect pancreatic beta-cell function by directly acting as HDAC inhibitors (promoting _β_-cell development, proliferation, and differentiation) or by indirectly increasing GLP-1 secretion from enteroendocrine L-cells (leading to insulin release). Furthermore, SCFAs reduce the release of proinflammatory cytokines by adipose tissue and weaken leukocyte activation. These anti-inflammatory effects improve insulin resistance, tissue glucose uptake, and blood glucose levels.
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References
- Stumvoll M, Goldstein BJ, Van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. The Lancet. 2005;365(9467):1333–1346. - PubMed
- de Vos WM, de Vos EAJ. Role of the intestinal microbiome in health and disease: from correlation to causation. Nutrition Reviews. 2012;70(supplement 1):S45–S56. - PubMed
- Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498:99–103. - PubMed
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