Inflammasome activation in response to dead cells and their metabolites - PubMed (original) (raw)
Review
Inflammasome activation in response to dead cells and their metabolites
Hajime Kono et al. Curr Opin Immunol. 2014 Oct.
Abstract
Cell death cannot go unnoticed. It demands that the surrounding cells clear away the corpses in a manner appropriate to the type of cell death. Dying cells represent a threat to the body that should be eliminated by the host immune response. Inflammasome activation followed by IL-1alpha release and IL-1beta maturation is crucial for tackling pathological conditions, including infections, whereas inflammasome activation precedes inflammatory pyroptotic cell death. On the other hand, recent studies have shown that the inflammasome plays an important role in the pathogenesis of metabolic diseases, including obesity, diabetes, and atherosclerosis. Here, we review current knowledge of the association between cell death, excess metabolites, and inflammasome activation as it relates to chronic inflammatory diseases.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Similar articles
- Regulation of interleukin 1α secretion by inflammasomes.
Yazdi AS, Drexler SK. Yazdi AS, et al. Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii96-9. doi: 10.1136/annrheumdis-2012-202252. Epub 2012 Dec 19. Ann Rheum Dis. 2013. PMID: 23253918 Review. - Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.
Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp J. Gross O, et al. Immunity. 2012 Mar 23;36(3):388-400. doi: 10.1016/j.immuni.2012.01.018. Immunity. 2012. PMID: 22444631 - Complex roles of inflammasomes in carcinogenesis.
Drexler SK, Yazdi AS. Drexler SK, et al. Cancer J. 2013 Nov-Dec;19(6):468-72. doi: 10.1097/PPO.0000000000000004. Cancer J. 2013. PMID: 24270345 Review. - Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β.
Angosto D, López-Castejón G, López-Muñoz A, Sepulcre MP, Arizcun M, Meseguer J, Mulero V. Angosto D, et al. Innate Immun. 2012 Dec;18(6):815-24. doi: 10.1177/1753425912441956. Epub 2012 Mar 28. Innate Immun. 2012. PMID: 22456941 - [Inflammasome--essential regulator of the inflammatory reaction].
Junttila I, Meri S, Rämet M. Junttila I, et al. Duodecim. 2013;129(7):705-11. Duodecim. 2013. PMID: 23720939 Review. Finnish.
Cited by
- A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer.
Dachani SR, Kaleem M, Mujtaba MA, Mahajan N, Ali SA, Almutairy AF, Mahmood D, Anwer MK, Ali MD, Kumar S. Dachani SR, et al. ACS Omega. 2024 Feb 22;9(9):10030-10048. doi: 10.1021/acsomega.3c09780. eCollection 2024 Mar 5. ACS Omega. 2024. PMID: 38463249 Free PMC article. Review. - Unraveling the Role of the NLRP3 Inflammasome in Lymphoma: Implications in Pathogenesis and Therapeutic Strategies.
Stergiou IE, Tsironis C, Papadakos SP, Tsitsilonis OE, Dimopoulos MA, Theocharis S. Stergiou IE, et al. Int J Mol Sci. 2024 Feb 17;25(4):2369. doi: 10.3390/ijms25042369. Int J Mol Sci. 2024. PMID: 38397043 Free PMC article. Review. - Cell Death Mechanisms in Cerebral Ischemia-Reperfusion Injury.
Zhang Q, Jia M, Wang Y, Wang Q, Wu J. Zhang Q, et al. Neurochem Res. 2022 Dec;47(12):3525-3542. doi: 10.1007/s11064-022-03697-8. Epub 2022 Aug 17. Neurochem Res. 2022. PMID: 35976487 Review. - Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions.
Qin C, Yang S, Chu YH, Zhang H, Pang XW, Chen L, Zhou LQ, Chen M, Tian DS, Wang W. Qin C, et al. Signal Transduct Target Ther. 2022 Jul 6;7(1):215. doi: 10.1038/s41392-022-01064-1. Signal Transduct Target Ther. 2022. PMID: 35794095 Free PMC article. Review. - Endothelialization and Inflammatory Reactions After Intracardiac Device Implantation.
Edlinger C, Paar V, Kheder SH, Krizanic F, Lalou E, Boxhammer E, Butter C, Dworok V, Bannehr M, Hoppe UC, Kopp K, Lichtenauer M. Edlinger C, et al. Adv Exp Med Biol. 2022;1401:1-22. doi: 10.1007/5584_2022_712. Adv Exp Med Biol. 2022. PMID: 35507133 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources