Comparison of the distribution of D-1 and D-2 dopamine receptors in the rat brain - PubMed (original) (raw)
Comparative Study
. 1989 May-Jun;2(3):119-37.
Affiliations
- PMID: 2528968
Comparative Study
Comparison of the distribution of D-1 and D-2 dopamine receptors in the rat brain
J K Wamsley et al. J Chem Neuroanat. 1989 May-Jun.
Abstract
The distribution of dopamine type 1 (D-1) and dopamine type 2 (D-2) receptors in the brain have been compared as assessed by the technique of autoradiography after labelling with highly selective ligands. D-1 receptors, as evidenced by the specific binding of [3H]R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-IH-3-benzazepine -7- ol (SCH 23390), were found in high concentrations in the caudate-putamen, nucleus accumbens, islands of Calleja, olfactory tubercle and the zona reticulata of the substantia nigra. A similar but distinct distribution was seen for [3H]sulpiride, a ligand which is highly selective for D-2 receptors. Like [3H]SCH 23390, this ligand also labelled the caudate-putamen, nucleus accumbens, islands of Calleja and the olfactory tubercle; however, only a very low density of D-2 receptors could be found in the zona reticulata of the substantia nigra, while a greater degree of binding was present in the zona compacta. Additional brain areas which contained D-1 but not D-2 receptors included the cerebral cortex, accessory olfactory nucleus, amygdala, thalamus, suprachiasmatic nucleus, choroid plexus, claustrum, endopiriform nucleus, zona incerta, dorsal lateral geniculate nucleus and the dentate gyrus. D-2 receptors were also found in areas which appeared to contain only low amounts of D-1 receptors such as the glomerular layer of the olfactory bulb, bed nucleus of the stria terminalis, hypothalamus, habenula, stratum lacunosum moleculare of the hippocampus, intermediate lobe of the pituitary, lateral mammillary nucleus, periaqueductal gray, inferior colliculus, nodulus of the cerebellum and the dorsal horn of the spinal cord. The results show the precise localization of dopamine receptors throughout the brain and provide a means of direct comparison between the distribution of dopamine receptor subtypes. These subtypes are pharmacologically and anatomically distinct entities and their comparison indicates areas where additional biochemical and neuroanatomical studies may be performed to elucidate the roles for these receptor subtypes in the central nervous system.
Similar articles
- Autoradiographic distribution of [3H]YM-09151-2, a high-affinity and selective antagonist ligand for the dopamine D2 receptor group, in the rat brain and spinal cord.
Yokoyama C, Okamura H, Nakajima T, Taguchi J, Ibata Y. Yokoyama C, et al. J Comp Neurol. 1994 Jun 1;344(1):121-36. doi: 10.1002/cne.903440109. J Comp Neurol. 1994. PMID: 7914895 - [3H]quinpirole binding to putative D2 and D3 dopamine receptors in rat brain and pituitary gland: a quantitative autoradiographic study.
Levant B, Grigoriadis DE, DeSouza EB. Levant B, et al. J Pharmacol Exp Ther. 1993 Feb;264(2):991-1001. J Pharmacol Exp Ther. 1993. PMID: 8437136 - Perinatal asphyxia induces long-term changes in dopamine D1, D2, and D3 receptor binding in the rat brain.
Chen Y, Hillefors-Berglund M, Herrera-Marschitz M, Bjelke B, Gross J, Andersson K, von Euler G. Chen Y, et al. Exp Neurol. 1997 Jul;146(1):74-80. doi: 10.1006/exnr.1997.6497. Exp Neurol. 1997. PMID: 9225740 - CNS distribution of D1 receptors: use of a new specific D1 receptor antagonist, [3H]SCH39166.
Wamsley JK, Alburges ME, McQuade RD, Hunt M. Wamsley JK, et al. Neurochem Int. 1992 Mar;20 Suppl:123S-128S. doi: 10.1016/0197-0186(92)90224-f. Neurochem Int. 1992. PMID: 1365410 Review. - The classification of dopamine receptors: relationship to radioligand binding.
Creese I, Sibley DR, Hamblin MW, Leff SE. Creese I, et al. Annu Rev Neurosci. 1983;6:43-71. doi: 10.1146/annurev.ne.06.030183.000355. Annu Rev Neurosci. 1983. PMID: 6220666 Review. No abstract available.
Cited by
- Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum.
Wong KLL, Nair A, Augustine GJ. Wong KLL, et al. Front Neural Circuits. 2021 May 13;15:658228. doi: 10.3389/fncir.2021.658228. eCollection 2021. Front Neural Circuits. 2021. PMID: 34054437 Free PMC article. Review. - Localization of D1a dopamine receptors on cell bodies and axonal endings in the substantia nigra pars reticulata of the rat.
Jan C, Muriel MP, Rolland AS, Hirsch EC, François C. Jan C, et al. J Neural Transm (Vienna). 2007;114(12):1509-17. doi: 10.1007/s00702-007-0775-8. Epub 2007 Jun 18. J Neural Transm (Vienna). 2007. PMID: 17576511 - Loss of dopamine D1 receptors and diminished D1/5 receptor-mediated ERK phosphorylation in the periaqueductal gray after spinal cord lesion.
Voulalas PJ, Ji Y, Jiang L, Asgar J, Ro JY, Masri R. Voulalas PJ, et al. Neuroscience. 2017 Feb 20;343:94-105. doi: 10.1016/j.neuroscience.2016.11.040. Epub 2016 Dec 5. Neuroscience. 2017. PMID: 27932310 Free PMC article. - Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration.
Cadet JL, Jayanthi S, McCoy MT, Beauvais G, Cai NS. Cadet JL, et al. CNS Neurol Disord Drug Targets. 2010 Nov;9(5):526-38. doi: 10.2174/187152710793361496. CNS Neurol Disord Drug Targets. 2010. PMID: 20632973 Free PMC article. Review. - Interplay among catecholamine systems: dopamine binds to alpha2-adrenergic receptors in birds and mammals.
Cornil CA, Ball GF. Cornil CA, et al. J Comp Neurol. 2008 Dec 10;511(5):610-27. doi: 10.1002/cne.21861. J Comp Neurol. 2008. PMID: 18924139 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Miscellaneous