Linkage disequilibrium in Huntington's disease: an improved localisation for the gene - PubMed (original) (raw)
Linkage disequilibrium in Huntington's disease: an improved localisation for the gene
R G Snell et al. J Med Genet. 1989 Nov.
Abstract
The search for the Huntington's disease gene has recently concentrated on the telomere of the short arm of chromosome 4. The evidence suggesting this position has been based on single crossover events, but there is conflicting evidence regarding the position of the gene relative to the most terminal markers. We have found significant linkage disequilibrium between the markers D4S98 (probe BS731B-C) and D4S95 (probe BS674E-D) and HD, which supports a localisation for the gene proximal to D4S90 and makes a telomeric localisation unlikely. This disequilibrium may also prove to be important in the future in allowing modification of risk estimates based on genetic linkage.
Similar articles
- Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.
Barron L, Curtis A, Shrimpton AE, Holloway S, May H, Snell RG, Brock DJ. Barron L, et al. J Med Genet. 1991 Aug;28(8):520-2. doi: 10.1136/jmg.28.8.520. J Med Genet. 1991. PMID: 1833548 Free PMC article. - Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.
Theilmann J, Kanani S, Shiang R, Robbins C, Quarrell O, Huggins M, Hedrick A, Weber B, Collins C, Wasmuth JJ, et al. Theilmann J, et al. J Med Genet. 1989 Nov;26(11):676-81. doi: 10.1136/jmg.26.11.676. J Med Genet. 1989. PMID: 2531224 Free PMC article. - Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3.
Andrew S, Theilmann J, Hedrick A, Mah D, Weber B, Hayden MR. Andrew S, et al. Genomics. 1992 Jun;13(2):301-11. doi: 10.1016/0888-7543(92)90246-o. Genomics. 1992. PMID: 1351866 - Huntington's disease.
Gusella JF. Gusella JF. Adv Hum Genet. 1991;20:125-51. Adv Hum Genet. 1991. PMID: 1839348 Review. No abstract available. - [Abnormal gene in Huntington's disease].
Kanazawa I. Kanazawa I. Tanpakushitsu Kakusan Koso. 1993 Feb;38(3):321-6. Tanpakushitsu Kakusan Koso. 1993. PMID: 8488266 Review. Japanese. No abstract available.
Cited by
- Recombination of 4p16 DNA markers in an unusual family with Huntington disease.
Pritchard C, Zhu N, Zuo J, Bull L, Pericak-Vance MA, Vance JM, Roses AD, Milatovich A, Francke U, Cox DR, et al. Pritchard C, et al. Am J Hum Genet. 1992 Jun;50(6):1218-30. Am J Hum Genet. 1992. PMID: 1350884 Free PMC article. - Expected behavior of conditional linkage disequilibrium.
Kaplan N, Weir BS. Kaplan N, et al. Am J Hum Genet. 1992 Aug;51(2):333-43. Am J Hum Genet. 1992. PMID: 1353663 Free PMC article. - Linkage disequilibrium mapping in isolated populations: the example of Finland revisited.
de la Chapelle A, Wright FA. de la Chapelle A, et al. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12416-23. doi: 10.1073/pnas.95.21.12416. Proc Natl Acad Sci U S A. 1998. PMID: 9770501 Free PMC article. - Linkage disequilibrium and modification of risk for Huntington disease.
Adam S, Theilmann J, Buetow K, Hedrick A, Collins C, Weber B, Huggins M, Hayden M. Adam S, et al. Am J Hum Genet. 1991 Mar;48(3):595-603. Am J Hum Genet. 1991. PMID: 1671809 Free PMC article. - Complex patterns of linkage disequilibrium in the Huntington disease region.
MacDonald ME, Lin C, Srinidhi L, Bates G, Altherr M, Whaley WL, Lehrach H, Wasmuth J, Gusella JF. MacDonald ME, et al. Am J Hum Genet. 1991 Oct;49(4):723-34. Am J Hum Genet. 1991. PMID: 1680285 Free PMC article.
References
- Nature. 1988 Apr 21;332(6166):734-6 - PubMed
- Genomics. 1989 Apr;4(3):397-407 - PubMed
- Am J Hum Genet. 1988 Feb;42(2):335-44 - PubMed
- J Med Genet. 1985 Dec;22(6):447-50 - PubMed
- Hum Genet. 1986 Aug;73(4):333-9 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical