Histone core modifications regulating nucleosome structure and dynamics - PubMed (original) (raw)

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doi: 10.1038/nrm3890. Epub 2014 Oct 15.

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• PMID: 25315270
• DOI: 10.1038/nrm3890

Review

Histone core modifications regulating nucleosome structure and dynamics

Peter Tessarz et al. Nat Rev Mol Cell Biol. 2014 Nov.

Abstract

Post-translational modifications of histones regulate all DNA-templated processes, including replication, transcription and repair. These modifications function as platforms for the recruitment of specific effector proteins, such as transcriptional regulators or chromatin remodellers. Recent data suggest that histone modifications also have a direct effect on nucleosomal architecture. Acetylation, methylation, phosphorylation and citrullination of the histone core may influence chromatin structure by affecting histone-histone and histone-DNA interactions, as well as the binding of histones to chaperones.

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