Cancer-like metabolism of the mammalian retina - PubMed (original) (raw)

Review

. 2015 May-Jun;43(4):367-76.

doi: 10.1111/ceo.12462. Epub 2014 Nov 7.

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Review

Cancer-like metabolism of the mammalian retina

Soo Khai Ng et al. Clin Exp Ophthalmol. 2015 May-Jun.

Abstract

The retina, like many cancers, produces energy from glycolysis even in the presence of oxygen. This phenomenon is known as aerobic glycolysis and eponymously as the Warburg effect. In recent years, the Warburg effect has become an explosive area of study within the cancer research community. The expanding knowledge about the molecular mechanisms underpinning the Warburg effect in cancer promises to provide a greater understanding of mammalian retinal metabolism and has motivated cancer researchers to target the Warburg effect as a novel treatment strategy for cancer. However, if the molecular mechanisms underlying the Warburg effect are shared by the retina and cancer, treatments targeting the Warburg effect may have serious adverse effects on retinal metabolism. Herein, we provide an updated understanding of the Warburg effect in mammalian retina.

Keywords: HIF-1; PKM2; Warburg effect; aerobic glycolysis; mammalian retina.

© 2014 Royal Australian and New Zealand College of Ophthalmologists.

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