Synaptic vesicle generation from central nerve terminal endosomes - PubMed (original) (raw)
Review
doi: 10.1111/tra.12235. Epub 2014 Nov 27.
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- PMID: 25346420
- DOI: 10.1111/tra.12235
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Review
Synaptic vesicle generation from central nerve terminal endosomes
Alexandros C Kokotos et al. Traffic. 2015 Mar.
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Abstract
Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain the fidelity of neurotransmission across a wide range of stimulation intensities. For this to be achieved, nerve terminals integrate a number of complementary endocytosis modes whose activation spans the breadth of these neuronal stimulation patterns. Two such modes are ultrafast endocytosis and activity-dependent bulk endocytosis, which are triggered by stimuli at either end of the physiological range. Both endocytosis modes generate endosomes directly from the nerve terminal plasma membrane, before the subsequent production of SVs from these structures. This review will discuss the current knowledge relating to the molecular mechanisms involved in the generation of SVs from nerve terminal endosomes, how this relates to other mechanisms of SV production and the functional role of such SVs.
Keywords: clathrin; dynamin; endocytosis; endosome; presynapse; vesicle.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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