Three-dimensional structure of the HSV1 nucleocapsid - PubMed (original) (raw)
Three-dimensional structure of the HSV1 nucleocapsid
J D Schrag et al. Cell. 1989.
Abstract
The three-dimensional structures of full and empty capsids of HSV1 were determined by computer analysis of low dose cryo-electron images of ice embedded capsids. The full capsid structure is organized into outer, intermediate, and inner structural layers. The empty capsid structure has only one layer which is indistinguishable from the outer layer of the full capsids. This layer is arranged according to T = 16 icosahedral symmetry. The intermediate layer of full capsids appears to lie on a T = 4 icosahedral lattice. The genomic DNA is located inside the T = 4 shell and is the component of the innermost layer of the full capsids. The outer and intermediate layers interact in such a way that the channels along their icosahedral two-fold axis coincide and form a direct pathway between the DNA and the environment outside the capsid.
Similar articles
- Three-dimensional structures of maturable and abortive capsids of equine herpesvirus 1 from cryoelectron microscopy.
Baker TS, Newcomb WW, Booy FP, Brown JC, Steven AC. Baker TS, et al. J Virol. 1990 Feb;64(2):563-73. doi: 10.1128/JVI.64.2.563-573.1990. J Virol. 1990. PMID: 2153224 Free PMC article. - Liquid-crystalline, phage-like packing of encapsidated DNA in herpes simplex virus.
Booy FP, Newcomb WW, Trus BL, Brown JC, Baker TS, Steven AC. Booy FP, et al. Cell. 1991 Mar 8;64(5):1007-15. doi: 10.1016/0092-8674(91)90324-r. Cell. 1991. PMID: 1848156 Free PMC article. - Breaking Symmetry in Viral Icosahedral Capsids as Seen through the Lenses of X-ray Crystallography and Cryo-Electron Microscopy.
Parent KN, Schrad JR, Cingolani G. Parent KN, et al. Viruses. 2018 Feb 7;10(2):67. doi: 10.3390/v10020067. Viruses. 2018. PMID: 29414851 Free PMC article. Review. - Transmission electron microscopy and the molecular structure of icosahedral viruses.
San Martín C. San Martín C. Arch Biochem Biophys. 2015 Sep 1;581:59-67. doi: 10.1016/j.abb.2015.06.001. Epub 2015 Jun 10. Arch Biochem Biophys. 2015. PMID: 26072114 Review.
Cited by
- Cellular Processes Induced by HSV-1 Infections in Vestibular Neuritis.
Zhao Z, Liu X, Zong Y, Shi X, Sun Y. Zhao Z, et al. Viruses. 2023 Dec 20;16(1):12. doi: 10.3390/v16010012. Viruses. 2023. PMID: 38275947 Free PMC article. Review. - Kaposi's Sarcoma-Associated Herpesvirus ORF67.5 Functions as a Component of the Terminase Complex.
Iwaisako Y, Watanabe T, Suzuki Y, Nakano T, Fujimuro M. Iwaisako Y, et al. J Virol. 2023 Jun 29;97(6):e0047523. doi: 10.1128/jvi.00475-23. Epub 2023 Jun 5. J Virol. 2023. PMID: 37272800 Free PMC article. - The Contribution of Kaposi's Sarcoma-Associated Herpesvirus ORF7 and Its Zinc-Finger Motif to Viral Genome Cleavage and Capsid Formation.
Iwaisako Y, Watanabe T, Futo M, Okabe R, Sekine Y, Suzuki Y, Nakano T, Fujimuro M. Iwaisako Y, et al. J Virol. 2022 Sep 28;96(18):e0068422. doi: 10.1128/jvi.00684-22. Epub 2022 Sep 8. J Virol. 2022. PMID: 36073924 Free PMC article. - Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane.
Aho V, Salminen S, Mattola S, Gupta A, Flomm F, Sodeik B, Bosse JB, Vihinen-Ranta M. Aho V, et al. PLoS Pathog. 2021 Dec 15;17(12):e1010132. doi: 10.1371/journal.ppat.1010132. eCollection 2021 Dec. PLoS Pathog. 2021. PMID: 34910768 Free PMC article. - Host Intrinsic and Innate Intracellular Immunity During Herpes Simplex Virus Type 1 (HSV-1) Infection.
Alandijany T. Alandijany T. Front Microbiol. 2019 Nov 8;10:2611. doi: 10.3389/fmicb.2019.02611. eCollection 2019. Front Microbiol. 2019. PMID: 31781083 Free PMC article. Review.