The insect microbiome modulates vector competence for arboviruses - PubMed (original) (raw)

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The insect microbiome modulates vector competence for arboviruses

Natapong Jupatanakul et al. Viruses. 2014.

Abstract

Diseases caused by arthropod-borne viruses (arboviruses), such as Dengue, West Nile, and Chikungunya, constitute a major global health burden and are increasing in incidence and geographic range. The natural microbiota of insect vectors influences various aspects of host biology, such as nutrition, reproduction, metabolism, and immunity, and recent studies have highlighted the ability of insect-associated bacteria to reduce vector competence for arboviruses and other pathogens. This reduction can occur through mechanisms, such as immune response activation, resource competition, or the production of anti-viral molecules. Studying the interactions between insect vectors and their microbiota is an important step toward developing alternative strategies for arbovirus transmission control.

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References

    1. Cleton N., Koopmans M., Reimerink J., Godeke G.-J., Reusken C. Come fly with me: Review of clinically important arboviruses for global travelers. J. Clin. Virol. 2012;55:191–203. doi: 10.1016/j.jcv.2012.07.004. -DOI -PubMed
    1. Reiter P. Yellow fever and dengue: A threat to Europe? Euro. Surveill. 2010;15:19509. -PubMed
    1. Soverow J.E., Wellenius G.A., Fisman D.N., Mittleman M.A. Infectious disease in a warming world: How weather influenced West Nile virus in the United States (2001–2005) Environ. Health Perspect. 2009;117:1049–1052. doi: 10.1289/ehp.0800487. -DOI -PMC -PubMed
    1. Weaver S.C., Reisen W.K. Present and future arboviral threats. Antivir. Res. 2010;85:328–345. doi: 10.1016/j.antiviral.2009.10.008. -DOI -PMC -PubMed
    1. Weaver S.C. Urbanization and geographic expansion of zoonotic arboviral diseases: Mechanisms and potential strategies for prevention. Trends Microbiol. 2013;21:360–363. doi: 10.1016/j.tim.2013.03.003. -DOI -PMC -PubMed

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