Geroscience: linking aging to chronic disease - PubMed (original) (raw)

. 2014 Nov 6;159(4):709-13.

doi: 10.1016/j.cell.2014.10.039.

Shelley L Berger 2, Anne Brunet 3, Judith Campisi 4, Ana Maria Cuervo 5, Elissa S Epel 6, Claudio Franceschi 7, Gordon J Lithgow 8, Richard I Morimoto 9, Jeffrey E Pessin 10, Thomas A Rando 11, Arlan Richardson 12, Eric E Schadt 13, Tony Wyss-Coray 14, Felipe Sierra 15

Affiliations

• PMID: 25417146
• PMCID: PMC4852871
• DOI: 10.1016/j.cell.2014.10.039

Geroscience: linking aging to chronic disease

Brian K Kennedy et al. Cell. 2014.

Abstract

Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.

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Figure 1

The Seven Pillars of Aging

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References

1. 1. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Nature. 2011;479:232–236. - PMC - PubMed
2. 1. Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. PLoS Biol. 2008;6:2853–2868. - PMC - PubMed
3. 1. Deelen J, Beekman M, Capri M, Franceschi C, Slagboom PE. BioEssays : news and reviews in molecular, cellular and developmental biology. 2013;35:386–396. - PMC - PubMed
4. 1. Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, et al. Aging Cell. 2014;13:273–282. - PMC - PubMed
5. 1. Heintz C, Mair W. Cell. 2014;156:408–411. - PMC - PubMed

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