c-di-AMP recognition by Staphylococcus aureus PstA - PubMed (original) (raw)
. 2015 Jan 2;589(1):45-51.
doi: 10.1016/j.febslet.2014.11.022. Epub 2014 Nov 28.
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- PMID: 25435171
- DOI: 10.1016/j.febslet.2014.11.022
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c-di-AMP recognition by Staphylococcus aureus PstA
Martina Müller et al. FEBS Lett. 2015.
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Abstract
Cyclic-di-AMP (c-di-AMP) is a bacterial secondary messenger involved in various processes, including sensing of DNA-integrity, cell wall metabolism and potassium transport. A number of c-di-AMP receptor proteins have recently been identified in Staphylococcus aureus. One of them - PstA - possesses a ferredoxin-like fold and is structurally related to the class of PII signal-transduction proteins. PII proteins are involved in a large number of pathways, most of them associated with nitrogen metabolism. In this study we describe the mode of c-di-AMP binding and subsequent structural changes of S. aureus PstA. An altered architecture in PstA compared to canonical PII proteins results in differences in ligand coordination.
Keywords: Bacterial signal transduction; Crystal structure; Cyclic-di-AMP; Ferredoxin-like fold; P(II)-related protein.
Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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