Protective effects of blueberry- and strawberry diets on neuronal stress following exposure to (56)Fe particles - PubMed (original) (raw)
Protective effects of blueberry- and strawberry diets on neuronal stress following exposure to (56)Fe particles
Shibu M Poulose et al. Brain Res. 2014.
Abstract
Particles of high energy and charge (HZE particles), which are abundant outside the magnetic field of the Earth, have been shown to disrupt the functioning of neuronal communication in critical regions of the brain. Previous studies with HZE particles, have shown that irradiation produces enhanced indices of oxidative stress and inflammation as well as altered neuronal function that are similar to those seen in aging. Feeding animals antioxidant-rich berry diets, specifically blueberries and strawberries, countered the deleterious effects of irradiation by reducing oxidative stress and inflammation, thereby improving neuronal signaling. In the current study, we examined the effects of exposure to (56)Fe particles in critical regions of brain involved in cognitive function, both 36h and 30 days post irradiation. We also studied the effects of antioxidant-rich berry diets, specifically a 2% blueberry or strawberry diet, fed for 8 weeks prior to radiation as well as 30 days post irradiation. (56)Fe exposure caused significant differential, neurochemical changes in critical regions of the brain, such as hippocampus, striatum, frontal cortex, and cerebellum, through increased inflammation, and increased oxidative stress protein markers. (56)Fe exposure altered the autophagy markers, and antioxidant-rich berry diets significantly reduced the accumulation of p62 in hippocampus, a scaffold protein that co-localizes with ubiquitinated protein at the 30 days post irradiation time-point. Exposure to (56)Fe particles increased the accumulation of disease-related proteins such as PHF-tau in the hippocampus of animals fed the control diet, but not in the irradiated animals fed the blueberry diet. These results indicate the potential protective effects of antioxidant-rich berry diets on neuronal functioning following exposure to HZE particles.
Keywords: Autophagy; Inflammation; Irradiation; Neurochemical; Oxidative stress.
Published by Elsevier B.V.
Similar articles
- Neurochemical differences in learning and memory paradigms among rats supplemented with anthocyanin-rich blueberry diets and exposed to acute doses of 56Fe particles.
Poulose SM, Rabin BM, Bielinski DF, Kelly ME, Miller MG, Thanthaeng N, Shukitt-Hale B. Poulose SM, et al. Life Sci Space Res (Amst). 2017 Feb;12:16-23. doi: 10.1016/j.lssr.2016.12.002. Epub 2016 Dec 15. Life Sci Space Res (Amst). 2017. PMID: 28212704 - Effects of age and diet on the heavy particle-induced disruption of operant responding produced by a ground-based model for exposure to cosmic rays.
Rabin BM, Joseph JA, Shukitt-Hale B. Rabin BM, et al. Brain Res. 2005 Mar 2;1036(1-2):122-9. doi: 10.1016/j.brainres.2004.12.041. Brain Res. 2005. PMID: 15725409 - Diet as a factor in behavioral radiation protection following exposure to heavy particles.
Rabin BM, Shukitt-Hale B, Joseph J, Todd P. Rabin BM, et al. Gravit Space Biol Bull. 2005 Jun;18(2):71-7. Gravit Space Biol Bull. 2005. PMID: 16038094 - Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Salminen A, et al. Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Prog Neurobiol. 2013. PMID: 23827971 Review. - Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review.
Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F. Giacalone M, et al. Nutr Neurosci. 2011 May;14(3):119-25. doi: 10.1179/1476830511Y.0000000007. Nutr Neurosci. 2011. PMID: 21756533 Review.
Cited by
- Food systems for long-term spaceflight: Understanding the role of non-nutrient polyphenols in astronauts' health.
Zhao M. Zhao M. Heliyon. 2024 Sep 5;10(19):e37452. doi: 10.1016/j.heliyon.2024.e37452. eCollection 2024 Oct 15. Heliyon. 2024. PMID: 39391512 Free PMC article. - Neuroprotective agents effective against radiation damage of central nervous system.
Lalkovicova M. Lalkovicova M. Neural Regen Res. 2022 Sep;17(9):1885-1892. doi: 10.4103/1673-5374.335137. Neural Regen Res. 2022. PMID: 35142663 Free PMC article. Review. - Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure.
Kiffer FC, Luitel K, Tran FH, Patel RA, Guzman CS, Soler I, Xiao R, Shay JW, Yun S, Eisch AJ. Kiffer FC, et al. Behav Brain Res. 2022 Feb 15;419:113677. doi: 10.1016/j.bbr.2021.113677. Epub 2021 Nov 21. Behav Brain Res. 2022. PMID: 34818568 Free PMC article. - Anthocyanins Promote Learning through Modulation of Synaptic Plasticity Related Proteins in an Animal Model of Ageing.
Vauzour D, Rendeiro C, D'Amato A, Waffo-Téguo P, Richard T, Mérillon JM, Pontifex MG, Connell E, Müller M, Butler LT, Williams CM, Spencer JPE. Vauzour D, et al. Antioxidants (Basel). 2021 Jul 31;10(8):1235. doi: 10.3390/antiox10081235. Antioxidants (Basel). 2021. PMID: 34439483 Free PMC article. - Sex-Specific Cognitive Deficits Following Space Radiation Exposure.
Parihar VK, Angulo MC, Allen BD, Syage A, Usmani MT, Passerat de la Chapelle E, Amin AN, Flores L, Lin X, Giedzinski E, Limoli CL. Parihar VK, et al. Front Behav Neurosci. 2020 Sep 16;14:535885. doi: 10.3389/fnbeh.2020.535885. eCollection 2020. Front Behav Neurosci. 2020. PMID: 33192361 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical