Prolactin: a versatile regulator of inflammation and autoimmune pathology - PubMed (original) (raw)

Review

Prolactin: a versatile regulator of inflammation and autoimmune pathology

Massimo Costanza et al. Autoimmun Rev. 2015 Mar.

Abstract

Prolactin (PRL) has long been proposed as an immune-stimulating and detrimental factor in autoimmune disorders. However, recent findings have challenged this common view, showing that PRL does not play a crucial role in the development of experimental autoimmune encephalomyelitis, animal model for multiple sclerosis (MS), and even protects against adjuvant-induced model of rheumatoid arthritis (RA). In this review we provide a critical overview of data supporting a role for PRL in the regulation of immune responses. In addition, we focus on studies exploring the involvement of PRL in autoimmune diseases, such as systemic lupus erythematosus, MS and RA, in light of the recently-outlined regenerative properties of this hormone.

Keywords: Inflammation; Multiple sclerosis; Prolactin; Rheumatoid arthritis; Systemic lupus erythematosus; Tissue repair.

PubMed Disclaimer

Cited by

Overview of Rheumatoid Arthritis and Scientific Understanding of the Disease.
Jahid M, Khan KU, Rehan-Ul-Haq, Ahmed RS. Jahid M, et al. Mediterr J Rheumatol. 2023 Aug 1;34(3):284-291. doi: 10.31138/mjr.20230801.oo. eCollection 2023 Sep. Mediterr J Rheumatol. 2023. PMID: 37941854 Free PMC article. Review.
The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).
Reckweg JT, Uthaug MV, Szabo A, Davis AK, Lancelotta R, Mason NL, Ramaekers JG. Reckweg JT, et al. J Neurochem. 2022 Jul;162(1):128-146. doi: 10.1111/jnc.15587. Epub 2022 Mar 8. J Neurochem. 2022. PMID: 35149998 Free PMC article. Review.
Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions.
Brinkmeyer-Langford C, Amstalden K, Konganti K, Hillhouse A, Lawley K, Perez-Gomez A, Young CR, Welsh CJ, Threadgill DW. Brinkmeyer-Langford C, et al. Int J Mol Sci. 2021 Oct 21;22(21):11379. doi: 10.3390/ijms222111379. Int J Mol Sci. 2021. PMID: 34768809 Free PMC article.
Prolactin has a pathogenic role in systemic lupus erythematosus.
Jara LJ, Medina G, Saavedra MA, Vera-Lastra O, Torres-Aguilar H, Navarro C, Vazquez Del Mercado M, Espinoza LR. Jara LJ, et al. Immunol Res. 2017 Apr;65(2):512-523. doi: 10.1007/s12026-016-8891-x. Immunol Res. 2017. PMID: 28130617
RNA-Seq analysis of European sea bass (Dicentrarchus labrax L.) infected with nodavirus reveals powerful modulation of the stress response.
Lama R, Pereiro P, Valenzuela-Muñoz V, Gallardo-Escárate C, Tort L, Figueras A, Novoa B. Lama R, et al. Vet Res. 2020 May 12;51(1):64. doi: 10.1186/s13567-020-00784-y. Vet Res. 2020. PMID: 32398117 Free PMC article.

Prolactin: a versatile regulator of inflammation and autoimmune pathology - PubMed (original) (raw)