Increment of Tal positive cells in peripheral blood from patients with rheumatoid arthritis - PubMed (original) (raw)
Affiliations
- PMID: 2549241
Increment of Tal positive cells in peripheral blood from patients with rheumatoid arthritis
H Nakao et al. J Rheumatol. 1989 Jul.
Abstract
Recently it was demonstrated that the Tal antigen is a marker for activated T cells and the population of Tal+ cells includes memory T cells. Our study was undertaken to analyze Tal+ cells in peripheral blood from patients with rheumatoid arthritis (RA) and examine the correlation between the proportion of Tal+ cells and disease activity. Using a dual immunofluorescent method, T cell subsets were analyzed in peripheral blood from 46 patients with RA, 10 patients with osteoarthritis (OA) and 10 healthy subjects. Patients with RA had a significantly higher percentage of T cells bearing the Tal antigen than patients with OA and healthy subjects. Furthermore, the percentage of CD3+Tal+ cells in peripheral blood from patients with RA was significantly correlated with disease activity including erythrocyte sedimentation rate, morning stiffness and the Lansbury index, whereas CD3+ HLA-DR+ cells did not correlate. In serial observations in patients with RA, the percentage of CD3+ Tal+ cells decreased in accordance with the improvement of disease activity. Thus, we suggest that the percentage of Tal+ cells may be a marker of the disease activity in patients with RA.
Similar articles
- Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis.
Yudoh K, Matsuno H, Nakazawa F, Yonezawa T, Kimura T. Yudoh K, et al. Arthritis Rheum. 2000 Mar;43(3):617-27. doi: 10.1002/1529-0131(200003)43:3<617::AID-ANR19>3.0.CO;2-B. Arthritis Rheum. 2000. PMID: 10728756 - Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis.
Fox RI, Fong S, Sabharwal N, Carstens SA, Kung PC, Vaughan JH. Fox RI, et al. J Immunol. 1982 Jan;128(1):351-4. J Immunol. 1982. PMID: 6976376 - Novel mechanisms of selective apoptosis in synovial T cells of patients with rheumatoid arthritis.
Hoa TT, Hasunuma T, Aono H, Masuko K, Kobata T, Yamamoto K, Sumida T, Nishioka K. Hoa TT, et al. J Rheumatol. 1996 Aug;23(8):1332-7. J Rheumatol. 1996. PMID: 8856610 - Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis.
Hartgring SA, van Roon JA, Wenting-van Wijk M, Jacobs KM, Jahangier ZN, Willis CR, Bijlsma JW, Lafeber FP. Hartgring SA, et al. Arthritis Rheum. 2009 Sep;60(9):2595-605. doi: 10.1002/art.24754. Arthritis Rheum. 2009. PMID: 19714586
Cited by
- Streptokinase promotes development of dipeptidyl peptidase IV (CD26) autoantibodies after fibrinolytic therapy in myocardial infarction patients.
Cuchacovich M, Gatica H, Vial P, Yovanovich J, Pizzo SV, Gonzalez-Gronow M. Cuchacovich M, et al. Clin Diagn Lab Immunol. 2002 Nov;9(6):1253-9. doi: 10.1128/cdli.9.6.1253-1259.2002. Clin Diagn Lab Immunol. 2002. PMID: 12414758 Free PMC article. - Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications.
Sperner-Unterweger B. Sperner-Unterweger B. Drugs. 2005;65(11):1493-520. doi: 10.2165/00003495-200565110-00004. Drugs. 2005. PMID: 16033289 Review. - Blood lymphocyte subsets in rats with adjuvant arthritis.
Franch A, Castellote C, Castell M. Franch A, et al. Ann Rheum Dis. 1994 Jul;53(7):461-6. doi: 10.1136/ard.53.7.461. Ann Rheum Dis. 1994. PMID: 7944619 Free PMC article. - Different regulatory effects of pentoxifylline on human T cell activation pathways.
Dong RP, Umezawa Y, Ikushima H, Munakata Y, Schlossman SF, Morimoto C. Dong RP, et al. J Clin Immunol. 1997 May;17(3):247-52. doi: 10.1023/a:1027362629161. J Clin Immunol. 1997. PMID: 9168405
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Research Materials
Miscellaneous