Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms - PubMed (original) (raw)
. 2015 Jan 27;9(1):52-61.
doi: 10.1021/nn505468v. Epub 2014 Dec 17.
Affiliations
- PMID: 25493329
- DOI: 10.1021/nn505468v
Dissecting the molecular mechanism of apoptosis during photothermal therapy using gold nanoprisms
Marta Pérez-Hernández et al. ACS Nano. 2015.
Abstract
The photothermal response of plasmonic nanomaterials can be exploited for a number of biomedical applications in diagnostics (biosensing and optoacoustic imaging) and therapy (drug delivery and photothermal therapy). The most common cellular response to photothermal cancer treatment (ablation of solid tumors) using plasmonic nanomaterials is necrosis, a process that releases intracellular constituents into the extracellular milieu producing detrimental inflammatory responses. Here we report the use of laser-induced photothermal therapy employing gold nanoprisms (NPRs) to specifically induce apoptosis in mouse embryonic fibroblast cells transformed with the SV40 virus. Laser-irradiated "hot" NPRs activate the intrinsic/mitochondrial pathway of apoptosis (programmed cell death), which is mediated by the nuclear-encoded proteins Bak and Bax through the activation of the BH3-only protein Bid. We confirm that an apoptosis mechanism is responsible by showing how the NPR-mediated cell death is dependent on the presence of caspase-9 and caspase-3 proteins. The ability to selectively induce apoptotic cell death and to understand the subsequent mechanisms provides the foundations to predict and optimize NP-based photothermal therapy to treat cancer patients suffering from chemo- and radioresistance.
Keywords: Bcl-2 family; NIR window; apoptosis; gold nanoparticles; mitochondrial pathway; nanoprism; photothermal.
Comment in
- Elucidating the fundamental mechanisms of cell death triggered by photothermal therapy.
Melamed JR, Edelstein RS, Day ES. Melamed JR, et al. ACS Nano. 2015 Jan 27;9(1):6-11. doi: 10.1021/acsnano.5b00021. Epub 2015 Jan 15. ACS Nano. 2015. PMID: 25590560 - Playing with nanoparticle shapes and laser powers to decide which route to take during photothermal therapy: apoptosis or necrosis?
Tortiglione C, Iachetta R. Tortiglione C, et al. Ann Transl Med. 2016 Oct;4(Suppl 1):S51. doi: 10.21037/atm.2016.10.09. Ann Transl Med. 2016. PMID: 27868019 Free PMC article. No abstract available.
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