Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake - PubMed (original) (raw)
. 2015 Feb 25;27(8):1402-7.
doi: 10.1002/adma.201404788. Epub 2014 Dec 22.
Affiliations
- PMID: 25529120
- DOI: 10.1002/adma.201404788
Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake
Jiashu Sun et al. Adv Mater. 2015.
Abstract
Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.
Keywords: biomedical applications; cellular uptake; core-shell nanoparticles; drug delivery; microfluidics.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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