Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs - PubMed (original) (raw)

. 1989 Nov 30;342(6249):505-11.

doi: 10.1038/342505a0.

Affiliations

• PMID: 2555717
• DOI: 10.1038/342505a0

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

N Watanabe et al. Nature. 1989.

Abstract

The Xenopus c-mos proto-oncogene product, pp39mos, accumulates in the unfertilized egg during maturation, is hyperphosphorylated and exhibits protein kinase activity. On fertilization, or soon after the completion of meiosis, the accumulated pp39mos undergoes selective proteolysis. Using an in vitro protease assay system, we show here that this specific proteolysis is caused by the calcium-dependent cysteine protease, calpain.

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Comment in

• Embryology. Under arrest in the cell cycle.
  Hunt T. Hunt T. Nature. 1989 Nov 30;342(6249):483-4. doi: 10.1038/342483a0. Nature. 1989. PMID: 2531291 No abstract available.

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