One-pot synthesis of multifunctional Au@graphene oxide nanocolloid core@shell nanoparticles for Raman bioimaging, photothermal, and photodynamic therapy - PubMed (original) (raw)

. 2015 Jun 3;11(21):2527-35.

doi: 10.1002/smll.201402269. Epub 2015 Jan 27.

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One-pot synthesis of multifunctional Au@graphene oxide nanocolloid core@shell nanoparticles for Raman bioimaging, photothermal, and photodynamic therapy

Young-Kwan Kim et al. Small. 2015.

Abstract

The paper reports a facile one-pot synthesis of core@shell nanoparticles (NPs) composed of Au core and graphene oxide nanocolloid (GON) shell. Unique properties of Au NPs and GON can be incorporated into a single nanohybrid structure to provide desirable functions for theranosis such as localized surface plasmon resonance, Raman scattering, amphiphilic surface, and photothermal conversion. Synthesis of Au@GON NPs is achieved by simple one-pot reaction in aqueous phase utilizing GON as a reducing and stabilizing agent without any additional reducing agent. The zinc phthalocyanine, a photosensitizer, loaded Au@GON NPs show excellent multifunctional properties for combinational treatment of photothermal and photodynamic therapy in addition to Raman bioimaging with low cytotoxicity.

Keywords: Raman spectroscopy; combination therapy; graphene oxide; nanoparticles; surface plasmon resonances.

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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