Urea for hyponatremia? - PubMed (original) (raw)
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doi: 10.1038/ki.2014.320.
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- PMID: 25635717
- DOI: 10.1038/ki.2014.320
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Urea for hyponatremia?
Richard H Sterns et al. Kidney Int. 2015 Feb.
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Abstract
Once the standard of care for cerebral edema, urea can also be used to treat hyponatremia. The 2014 European Clinical Practice Guidelines recommend urea for the treatment of the syndrome of inappropriate antidiuretic hormone, while discouraging use of vasopressin antagonists. Although there is evidence that urea can diminish hypertonic injury to brain cells caused by rapid correction of hyponatremia, clinical trials are needed that include patients at high risk to develop complications from overcorrection.
Comment on
- Urea minimizes brain complications following rapid correction of chronic hyponatremia compared with vasopressin antagonist or hypertonic saline.
Gankam Kengne F, Couturier BS, Soupart A, Decaux G. Gankam Kengne F, et al. Kidney Int. 2015 Feb;87(2):323-31. doi: 10.1038/ki.2014.273. Epub 2014 Aug 6. Kidney Int. 2015. PMID: 25100046
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